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心脏型脂肪酸结合蛋白在早期急性心肌梗死诊断中的价值 被引量:3

Significance of heart-type fatty acid binding protein in diagnosis of early acute myocardial infarction
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摘要 [目的]研究血浆心型脂肪酸结合蛋白(H-FABP)在早期急性心肌梗死(AMI)诊断中的价值。[方法]选择2008年5月~2008年12月因胸痛就诊于大连医科大学附属第一医院,被确诊为急性心肌梗死的患者为对象,共收集27例,选择正常对照50名,为体检健康者。采用免疫胶体金渗透方法定性检测正常对照和急性心梗患者发病3 h内血浆的H-FABP,并与心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶质量(MMB)和肌酸激酶(CK)的检测结果进行比较。[结果]H-FABP在急性心梗病人发病3 h内诊断早期AMI的阳性率(96%)明显高于cTnI(68%)、MMB(23%)和CK(24%)(P〈0.05)。[结论]H-FABP对于诊断早期AMI具有较高的敏感性和良好的特异性,其对早期急性心肌梗死的诊断敏感性优于cTnI、MMB、CK。 [ Objective] To study the value of heart-type fatty acid binding protein (H-FABP) in the diagnosis of early acute myocardial infarction (AMI) . [ Method ] The plasma level of H - FABP was measured by sandwich ELISA in 27 patients with suspected AMI at admission within 3 hours after onset of chest pain and 50 normal healthy subjects. The plasma rations of cardiac troponin- I (cTnI), the quality of creatine kinase isoenzyme-MMB and creation phospholinase (CK) were assayed at the same time by using automatic biochemical analyzer. [ Result] The diagnostic positive rate (96%) of H - FABP for AMI within 3 hours after onset of chest pain, was significantly higher than that of cTnl (68 % ), MMB (23 % ), CK(24% ) (P 〈0.05). [ Conclusion] H- FABP seems to be a useful biochemical cardiac marker for AMI in the early stage.
出处 《大连医科大学学报》 CAS 2009年第6期714-715,724,共3页 Journal of Dalian Medical University
关键词 脂肪酸结合蛋白 急性心肌梗塞 早期诊断 fatty acid--binding protein acute myocardial infarction diagnosis of early stage
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