摘要
目的:探讨尿微量白蛋白(mALB)、血清胱抑素C(CysC)和β2-微球蛋白(β2-MG)联合检测对糖尿病肾病早期诊断的价值。方法:根据尿微量白蛋白排泄率将115例2型糖尿病患者分为糖尿病无肾病组、糖尿病早期肾病组和糖尿病临床肾病组,45例健康体检人员为对照组;检测并比较4组mALB、血清CysC和β2-MG水平并进行相关分析。结果:糖尿病无肾病组尿mALB、血清CysC和β2-MG均明显高于对照组,差异有统计学意义(P<0.05);糖尿病早期肾病组尿mALB、血清CysC和β2-MG均明显高于对照组和糖尿病无肾病组,差异有统计学意义(P<0.05);糖尿病临床肾病组尿mALB、血清CysC和β2-MG均明显高于对照组、糖尿病无肾病组和糖尿病早期肾病组,差异有统计学意义(P<0.05);3项指标联合检测的阳性率明显高于单项检测的阳性率;CysC和β2-MG与mALB呈正相关。结论:尿mALB、血清CysC和β2-MG都可作为糖尿病早期肾损害的敏感指标,联合检测对糖尿病肾病早期诊断具有重要的临床价值。
Objective：To study the urine trace albumin （mALB）, serum cystatin C （CysC） and beta 2-micro- globulin （beta 2-MG） joint detection value in the early diagnosis of diabetic nephropathy. Method：According to the urine trace albumin excretion rate, 115 cases of patients with type 2 DM diabetes were divided into without kidney disease clinical group, the early diabetic nephropathy group and diabetes nephropathy group,and 45 cases of medi- cal health persons were healthy controls. The results of urinary mALB, serum CysC and beta 2-MG level between groups were compared. Result：The urinary mALB, serum CysC and beta 2-MG of the diabetic nephropathy group were significantly higher than those of healthy control group, which differences were statistically significant （P〈0.05）. Urinary mALB, serum CysC and beta 2-MG of the early diabetic nephropathy group were significantly higher than those of the healthy control group and diabetes without kidney disease group, which differences were statistically significant （P〈0.05）. Urinary mALB, serum CysC and beta 2-MG of clinical diabetes nephropathygroup were significantly higher than those of the healthy control group, diabetic nephropathy group and early dia betic nephropathy group, which differences were statistically significant （P〈0.05）. The positive rate of combined detection of three indicators was obviously higher than that of single detection. CysC and beta 2-MG were positive ly correlated with mALB. Conclusion：Urinary mALB, serum CysC and beta 2-MG could be as sensitive indicators of early renal damage of diabetes,and combined detection might have important clinical value for early diagnosis of diabetic nephropathy.
出处
《临床血液学杂志（输血与检验）》
CAS
2014年第6期1025-1027,共3页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
