摘要
目的:研究蚕蛹短肽肠内营养(EN)制剂和蚕蛹蛋白EN制剂对高脂饲料和链脲佐菌素诱导的2型糖尿病(T2DM)小鼠代谢特性的影响。方法:糖尿病小鼠分为5组(n=10只),分别是空白组、益力佳组、蚕蛹短肽1组、蚕蛹短肽2组及蚕蛹蛋白组,并随机选取10只正常小鼠作为对照组。各组小鼠采用对应EN制剂支持四周并测定其空腹血糖值(FBG)、口服葡萄糖耐量及血清生化指标。结果:DM小鼠在接受以蚕蛹短肽或蚕蛹蛋白为蛋白源的EN制剂支持两周后其FBG值均能显著降低(p<0.01),相对于空白组,短肽1组、短肽2组和蚕蛹蛋白组的FBG水平分别降低了47.47%、38.14%和41.52%。同时,以蚕蛹短肽为蛋白源的EN制剂能显著改善糖尿病小鼠的葡萄糖耐量(p<0.01);蚕蛹短肽或蚕蛹蛋白为蛋白源EN制剂还能明显降低糖尿病小鼠的总胆固醇(TC)(p<0.01)、总甘油三脂(TG)及低密度脂蛋白(LDL)含量。结论:以蚕蛹短肽或蚕蛹蛋白为蛋白质来源的特殊医学用途配方食品能显著降低2型糖尿病小鼠血糖值,并有一定的调节血脂代谢的作用。
Objective：The present study was designed to investigate the silkworm pupa protein or peptide-based enteral formula for improving metabolic characteristic in streptozotocin-induced type 2 diabetes mellitus （T2DM） mice. Method .T2DM mice model was randomly assigned to 5 groups （ n = 10/group）.The 1 st group, blank group fed with Standard chow, the 2nd and 3rd group fed with Abbott Glucerna SR and silkworm pupae peptide sample 1-based EN （sppl）, respectively.The 4tn and 5th group fed with silkworm pupae peptide sample 2-based EN （spp2） and silkworm pupae protein sample 3-based EN （spp3）, respectively.The levels of fasting blood glucose （FBG）, oral glucose tolerance test （OG-FI-）and blood biochemical indices were determined. Results, The SPP Enteral Formula could significantly reduce blood glucose in T2DM mice（ p 〈 0.01 ） compared with the control group. FBG of spp!, spp2 and spp3 was decreased with the value of 4？.4？%, 38.14% and 41.52%, respectively.The results of OGTT showed that two SPP groups were increased significantly（ p 〈 0.01 ）.The level of blood biochemical indices including TC, TG and LDL were decreased in the 3rd and 4th group, which use SPP- based EN. Conclusion.SPP- based Enteral Formula marked decreased the levels of T2DM mice blood glucose. It also showed the actively effect of improving lipid metabolism.
出处
《食品工业科技》
CAS
CSCD
北大核心
2014年第23期342-346,共5页
Science and Technology of Food Industry
基金
上海市科委工程中心建设项目(11DZ2280300)
上海海洋大学科技发展专项基金
关键词
蚕蛹蛋白
糖尿病
肠内营养
肠内营养支持制剂
Silkworm pupa protein
type 2 Diabetes mellitus
enteral nutrition
enteral nutrition support formula
