摘要
目的研究吡格列酮联合生活方式干预对多囊卵巢综合征的临床疗效。方法将确诊为多囊卵巢综合征的86例患者随机分成观察组和对照组,各43例。对照组仅服用吡格列酮,观察组在此基础上配合生活方式干预。比较治疗3月后,患者月经和排卵情况,性激素、血糖和血脂、抵抗素和脂联素变化情况以及人体一般指标变化。结果观察组月经排卵改善率为95.35%,明显高于对照组的79.07%(P<0.05)。与治疗前比较,两组促黄体生成素(LH)、雄激素(T)以及促黄体生成素/促卵泡生成素(LH/FSH)比值,血糖指标空腹血糖(FPG)、空脂血清胰岛素(FINS)、胰岛素抵抗指数(IR),血脂指标血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),抵抗素(RST)和脂联素(APN)水平,质量、体重指数(BMI)、腰围,治疗后改善均具有统计学意义(P<0.05),且除FSH指标外其余指标观察组的改善情况均显著优于对照组(P<0.05)。结论吡格列酮联合生活方式干预治疗多囊卵巢综合征临床疗效好,对患者各项指标均有良好的改善作用,值得临床推广。
Objective To study the effect of pioglitazone combined with lifestyle intervention in the treatment of polycystic ovarian syn-drome （ PCOS ） . Methods 86 cases of PCOS in our hospital were randomly divided into the observation group and the control group, 43 cases in each group. The control group used pioglitazone alone, while on this basis the observation group was given the lifestyle inter-vention. The menstruation and ovulation situation, changes of sex hormones, blood glucose, blood lipid, adiponectin （ APN ） , resistin （ RST ） and general indexes of human body after 3-month treatment were compared. Results The improvement rate of menstruation and ovula-tion was 95. 35% in the observation group, which was significantly higher than 79. 07% in the control group （ P〈0. 05 ） . Compared with before treatment, the changes of luteinizing hormone （ LH ） , testosterone （ T ） and LH/FSH ratio;blood glucose indexes of FPG, FINS and IR and lipid indexes of TC,TG,LDL and HDL;RST and APN;mass, body mass index （ BMI ） , waist circumference before and after treatment had statistically significant differences between the observation group and the control group （ P〈0. 05 ）; moreover except FSH, the im-provement situation of other indexesin the observation group were significantly superior to the control group （ P〈0. 05 ） . Conclusion Pi-oglitazone combined with lifestyle intervention in the treatment of PCOS has good clinical efficacy, can improve various indexes and de-serves to be promoted in clinic.
出处
《中国药业》
CAS
2014年第17期26-28,共3页
China Pharmaceuticals
