摘要
目的:探讨二甲双胍合并克罗米芬在治疗多囊卵巢综合征中的作用,为多囊卵巢综合征的治疗提供合理依据。方法:80例患者给予二甲双胍合并克罗米芬治疗,比较治疗前后临床症状、内分泌和生化指标的变化情况,与单一给予克罗米芬促排卵治疗比较排卵、妊娠情况。结果:用药后体重指数(BMI)、腰臀比(WHR)、空腹胰岛素(FINS)、睾酮(T)促黄体生成素(LH)、LH/FSH明显下降,P<0.05;雌二醇(E2)、促卵泡生成素(FSH)改变不明显,联合用药后排卵、妊娠率明显高于单一克罗米芬治疗,P<0.05。结论:二甲双胍合并克罗米芬可改善临床症状,提高排卵、妊娠率,降低LH/FSH比值、LH、T水平,提高胰岛素的敏感性。
Objective： To assess the clinical effect of clomiphene and metformin on polycystic ovary syndrome （P- COS）, and to evaluate those parameters to provide a theoretical basis for the reasonable treatment of PCOS. Methods： Eighty patients diagnosed as PCOS were given clomiphene and metformin. The changes of symptom, incretion and biochemical parameters were observed. The chances of ovulation and pregnancy with only use clomiphene were observed. Results： After the treatment of clomiphene combined with metformin, body nass index （BMI）, waist hip ratio （WHR）, luteinizing hormone （LH）, the ratio of LH and follicule stimulation hormone （LH/ FSH）, tesosterone （T）and fasting insulin （FINS） declined （P〈0.05）, the changes of estradiol （E2） and follicule stimulation hormone （FSH） can not be seen, clomiphene combined with metformin are better than clomiphene in ovulation and pregnancy. Conclusion： Clomiphene combined with metformin may be clinically useful in PCOS patients. It resultes in the decline in LH/FSH, LH, T levels, and improves the sensitivity of insulin, improves the chance of ovulation and pregnancy.
出处
《华西医学》
CAS
2009年第5期1244-1246,共3页
West China Medical Journal
