摘要
目的探讨分析H-FABP、NT-proBNP、CRP、cTnT在ACS患者预后中的评估价值。方法 96例ACS患者根据随访1年内患者是否发生不良心血管事件将所有患者分为预后不良组(35例)与对照组(61例)。于患者入院后检测H-FABP、NT-proBNP、CRP、cTnT四项指标的水平,并于出院后进行为期1年的随访,绘制受试者工作特性曲线来测定上述四项指标对ACS患者预后评估的准确性,并找出出院后发生不良心血管事件的危险因素。结果入院时预后不良组H-FABP、NT-proBNP、CRP、cTnT水平均明显高于对照组(P<0.05);H-FABP、NT-proBNP、CRP、cTnT检测对预测心血管不良事件的ROC曲线下面积与临界值分别为0.811、40.95μg/L,0.749、1342.98ng/L,0.788、9.69mg/L,0.812、0.78μg/L;COX单因素回归分析显示H-FABP、NT-proBNP、CRP及cTnT水平的升高是ACS患者发生心血管不良事件的危险因素(P<0.05)。结论 H-FABP、NT-proBNP、CRP、cTnT对ACS患者的预后有着较高的评估价值,值得推广。
Objective To study the prognostic value of H-FABP,NT-proBNP,CRP and cTnT in patients with ACS.Methods 96 patients with ACS were divided into the poor prognosis group（35cases）and control group（61cases）according to the occurrence of adverse cardiovascular events.Level of H-FABP,NT-proBNP,CRP and cTnT was tested after the admission of the patients.A one-year follow-up was carried out after the discharge and ROC was plotted to determine the accuracy of the four indicators of prognosis of patients with ACS.In the same time,risk factors for adverse cardiovascular events were also found out.Results Level of H-FABP,NT-proBNP,CRP and cTnT of poor prognosis group was statistically higher than that of the control group（P0.05）;AUC and cutoff value H-FABP,NTproBNP,CRP,cTnI detection of adverse cardiovascular events were 0.811,40.95μg/L,0.749,,1342.98ng/L,0.788,9.69mg/L,0.812,0.78μg/L;COX analysis showed that COX H-FABP,NT-proBNP,CRP,and elevated cTnT levels in patients with ACS is a risk factor for cardiovascular adverse events（P0.05）.Conclusion H-FABP,NT-proBNP,CRP and cTnT has high prognostic value in patients with ACS,which is worth promoting.
出处
《中国实验诊断学》
2014年第8期1273-1275,共3页
Chinese Journal of Laboratory Diagnosis
基金
国家自然科学基金(81071413)
