摘要
【目的】观察血清γ谷氨酰转移酶（GGT）和血浆丙二醛（MDA）在冠心病人群中的变化，探讨GGT和MDA在冠心痛患者中的临床意义。【方法】选择冠脉造影确诊的冠心病患者及对照组共157例，分成四组，对照组40例，稳定型心绞痛（SAP组）38例，非ST抬高型急性冠脉综合征（NSTE-ACS组）41例和ST抬高型急性冠脉综合征（STE—ACS组）40例，分别测定其GGT、MAD水平并进行组问比较。【结果】NSTE—ACS组和STE-ACS组中GGT、MAD明显高于对照组及SAP组（P〈0．01）。【结论】氧化应激参与急性冠脉综合征的病理生理过程，抗氧化治疗可能对冠心病治疗有重要意义。
[Objective] To observe the change of serum malondialdehyde（MDA） and gamma-glutamyl transferase（GGT） in patients with coronary heart disease and to explore the clinical significance of MDA and GGT in patients with coronary heart disease. [Methods] A total of 157 patients with coronary heart disease confirmed by coronary angiography were divided into 4 groups including control group（ n = 40）, stable angina pectoris group（SAP group, n ~ 38）, non-ST-segment elevation acute coronary syndrome group （NSTE-ACS group, n =41） and ST-segment elevation acute coronary syndrome group（STE-ACS group, n = 40）. Plasma levels of MDA and GGT were measured and compared among groups. [Results] Plasma levels of MDA and GGT in NSTE-ACS group and STE-ACS group were significantly higher than those in control group and SAP group（ P 〈0.01）. [Conclusion] Oxidative stress participates the pathological process of acute coronary syndrome. Anti-oxidation therapy may be important to the treatment of coronary heart disease.
出处
《医学临床研究》
CAS
2013年第5期891-893,共3页
Journal of Clinical Research
关键词
冠心病
血液
Γ谷氨酰转移酶
血液
丙二醛
血液
Coronary Disease/BL
gamma-Glutamyltransferase/BL
Malondialdehyde/BL
