摘要
目的探讨2型糖尿病并发脑梗死患者联合检测血浆血管性假性血友病因子(vWF)与血小板参数的临床价值。方法选取2011年12月—2013年10月2型糖尿病并发脑梗死患者32例,设为糖尿病并发脑梗死组,同期32例2型糖尿病患者设为糖尿病组,同期健康体检者30例设为对照组。检测3组糖化血红蛋白(HbA1c)、血vWF水平及血小板各参数,观察其差异及HbA1c与血vWF水平、血小板参数的关系。结果糖尿病并发脑梗死组、糖尿病组和对照组的HbA1c、血vWF水平呈逐步下降趋势,组间比较有显著差异(P<0.01)。3组血小板计数(PLT)无显著差异(P>0.05);血小板分布宽度(PDW)及血小板平均体积(MPV)在3组中呈逐步下降趋势,组间比较具有显著差异(P<0.01);HbA1c与vWF、MPV、PDW呈正相关(P<0.01)。结论 2型糖尿病并发脑梗死患者血vWF水平显著升高,联合检测血vWF与血小板各参数可为早期诊断与治疗提供参考。
Objective To explore the clinical significance of plasma vWF and platelet parameters in patients with type 2 diabetes mellitus（T2DM） complicated with cerebral infraction. Methods A total of 32 patients with T2 DM complicated with cerebral infraction from December 2011 to October 2013 and another 32 patients with single T2 DM were selected as combination group and T2 DM group,while another 30 healthy people served as control group. Glycated hemoglobin（HbA1c） level,von Willebrand factor（vWF） level and platelet parameters were detected in 3 groups to observe their differences and the relationship between HbA1 c level and vWF level and platelet parameters were analyzed. Results HbA1 c and vWF levels decreased gradually in combination and T2 DM groups than that in control group,and the differences were significant（P〈0. 01）. There was no significant difference in platelet count（PLT） among 3 groups（P 〉0. 05）. However,platelet distribution width（PDW） and mean platelet volume（MPV） decreased evidently and gradually in 3 groups（P 0.01）.Additionally,HbA1 c level was positive associated with vWF,PMV and PDW（P〈0. 01）. Conclusion Level of vWF increases significantly in patients with T2 DM complicated with cerebral infarction,whose detection combined with platelet parametes can provide references for the early diagnosis and treatment.
出处
《实用临床医药杂志》
CAS
2014年第16期22-24,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321578)
