摘要
目的:研究碱性成纤维细胞生长因子(basic Fibroblast growth factor,bFGF)对热射病大鼠模型ET21、VWF、VEGF水平的影响。方法:选择SD大鼠36只随机分为6组,每组个6只,建立热射病大鼠模型后分为模型组、常温组、常温bFGF组、降温组、降温bFGF组,建模后0 h、2 h,比较不同级别生命征、血管功能因子。结果:建模后0 h,模型组Tr、HR、RR、MAP明显高于空白组(P<0.05);建模后2 h,常温bFGF组、降温bFGF组明显低于常温组、降温组,降温组、降温bFGF组明显低于常温组、常温bFGF组(P<0.05)。建模后0 h,模型组ET21、VWF的含量均明显高于空白组,VEGF含量明显低于热空白组(P<0.05);建模后2 h,常温组ET21、VWF明显升高,VEGF明显降低,常温bFGF组、降温组、降温bFGF组ET21、VWF明显降低,VEGF明显升高(P<0.05);降温组、降温bFGF组ET21、VWF明显低于常温组、常温bFGF组,VEGF明显高于常温组、常温bFGF组(P<0.05);常温bFGF组、降温bFGF组ET21、VWF明显低于常温组与降温组,VEGF明显高于常温组与降温组(P<0.05)。结论:碱性成纤维细胞生长因子有助于改善热射病大鼠生命体征,调节血管功能因子含量,提高热射病大鼠预后。
Objective： To study the effect of basic fibroblast growth factor on the expression levels ofET21, VWF, VEGF in heat- stroke rats. Methods： 36 SD rats were divided into six groups randomly into six groups of six months, the establishment of heatstroke af- ter rats were divided into model group, normothermia group, bFGF group at room temperature, cooling group, cooling bFGF group, 0 h, 2h, compare different levels of life, vascular function factor after modeling. Results： After modeling Oh, model group Tr, HR, RR, MAP was significantly higher than the control group （P〈0.05）; after modeling 2 h, room temperature bFGF group and bFGF group was signifi- cantly lower than the normal temperature cooling group, cooling group, cooling group cooling bFGF group was significantly lower than the normal temperature group, normothermia bFGF group （P〈0.05）. After modeling 0 h, model group ET21, VWF levels were significantly higher than the control group, VEGF were significantly lower than the thermal control group （P〈0.05）; 2 h, normothermia group ET21, VWF significantly increased after model, VEGF significantly reduced, bFGF group at room temperature, cooling group, cooling bFGF group ET21, VWF decreased, VEGF was significantly higher （P〈0.05）; the cooling group, cooling bFGF group ET21, VWF group was significantly lower than the normal temperature, room temperature bFGF group, VEGF was significantly higher than that group room temperature, room temperature bFGF group （P〈0.05）; bFGF group at room temperature, cooling bFGF group ET21, VWF group was sig- nificantly lower than the normal temperature and cooling group, VEGF group was significantly higher than normal temperature and cool- ing group （P〈0.05）. Conclusion： Basic fibroblast growth factor help to improve vital signsthe of heatstroke rats, regulate blood vessel function factor levels, and improve the prognosis of heatstroke rats.
出处
《现代生物医学进展》
CAS
2017年第7期1225-1228,1258,共5页
Progress in Modern Biomedicine
基金
南京军区医学科技创新课题基金项目(MS130)
