摘要
目的 探讨血浆抗凝血酶Ⅲ活性和纤维蛋白原水平在冠心病患者中的临床应用.方法 测定急性心肌梗死（AMI）组、不稳定型心绞痛（UA）组、稳定型心绞痛（SA）组和健康对照组血浆抗凝血酶Ⅲ活性和纤维蛋白原水平,并进行比较.结果 AMI组、UA组及SA组血浆AT-Ⅲ活性（％）分别为89.04±13.32,86.64±11.07和102.33±9.39.AMI组、UA组及SA组血浆AT-Ⅲ活性与对照组比较,差异均有统计学意义（P＜0.05）.AMI组、UA组及SA组血浆Fib含量（g/L）分别为3.93±1.42,3.83±1.12和3.20±0.73.AMI组和UA组血浆Fib水平与对照组比较,差异有统计学意义（P＜0.05）;AMI组和UA组血浆AT-Ⅲ活性较SA组明显降低,差异有统计学意义（P＜0.05）.结论 AT-Ⅲ活性及Fib水平的变化是鉴别各种冠心病发生的敏感性指标.
Objective To explore the clinical application of plasma anti-thrombin Ⅲ activity and fibrinogen level in patients with coronary heart disease.Methods Plasma anti-thrombin Ⅲ （AT-Ⅲ） activity and Fibrinogen （FIB） level were detected in patients with acute myocardial infarction（AMI）,unstable angina （UA） and stable angina（SA）.The results were compared among 3 groups and normal controls.Results Plasma anti-thrombin Ⅲ activity in patients with AMI,UA and SA （％） were respectively 89.04±13.32,86.64±11.07 and 102.33±9.39.There were significant differences of plasma antithrombin Ⅲ activity in patients with AMI,UA and SA compared with normal controls （P＜0.05）.Plasma fibrinogen levels in patients with AMI,UA and SA （g/L） were respectively 3.93±1.42,3.83±1.12 and 3.20±0.73,respectively.Fibrinogen levels in AMI and UA groups were significantly different from normal controls.Anti-thrombin Ⅲ activity in AMI,UA groups decreased significantly than in SA group.Conclusion Anti-thrombin Ⅲ activity and fibrinogen levels are sensitive index for the differential diagnosis of specific coronary heart disease.
出处
《现代检验医学杂志》
CAS
2014年第3期141-143,共3页
Journal of Modern Laboratory Medicine
关键词
冠心病
抗凝血酶Ⅲ
纤维蛋白原
coronary heart disease
anti-thrombin Ⅲ
fibrinogen
