摘要
血清降钙素原(PCT)是提示细菌感染的一种重要指标,目前已被用于指导部分感染性疾病的诊治。在腹腔感染(IAI)患者中,PCT被证明有助于IAI的早期诊断、与IAI的严重程度存在相关性并有助于指导IAI的抗生素治疗。但在PCT对IAI早期诊断临界值的确定,与C反应蛋白相比是否具有优势,能否进一步用作IAI严重程度分级以及指导IAI患者停用抗生素的截止值方面目前尚有争议。文章主要就PCT在感染性疾病诊治及IAI的早期诊断、严重程度评价、抗生素治疗中的指导作用进行综述。
Serum procalcitonin(PCT),an important diagnostic biomarker for bacterial infection,has been used to guide the diagnosis and treatment in some infectious diseases.PCT has been proven to be helpful for the early diagnosis and guiding the antibiot ic treatment of intra-abdominal infection(IAI),and it is related to the severity of IAI.However,it is still controversial whether PCT has the advantage of early diagnosis compared with C-reactive protein(CRP),whether it can be further used in severity grading of IAI.And either the critical value of PCT to the early diagnosis of IAI or the cutoff ranges of PCT to stop using antibiotics in patients with IAI is still uncertain.In this review,we discuss the value of PCT in the early diagnosis,severity evaluation and antibiotic treatment of IAI and other infectious diseases.
作者
王江(综述)
王建忠(审校)
WANG Jiang;WANG Jian-zhong(School of the First Clinical Medicine,Gannan Medical University,Ganzhou 341000,Jiangxi,China;Department of Gastrointestinal Surgery,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,Jiangxi,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第10期1110-1114,共5页
Journal of Medical Postgraduates
基金
江西省教育厅科学技术研究项目基金(GJJ160980)
关键词
降钙素原
腹腔感染
诊断
抗生素
严重程度
procalcitonin
intraabdominal infections
diagnosis
anti-bacterial agents
severity
