摘要
目的:分析我院药品不良反应(ADR)的发生特点,为临床合理用药提供参考。方法:对我院2012年9月至2013年9月上报的225例ADR报告,从患者的性别、年龄、引发ADR的给药途径、药品种类、ADR累及器官或系统及临床表现、ADR严重程度及转归等方面进行回顾性分析。结果:女性ADR发生率高于男性,年龄在60岁以上的患者ADR发生率较其他年龄段高;静脉给药是引发ADR的主要给药途径;ADR涉及的药品种类以抗菌药物、中药制剂较多;ADR临床表现主要是消化系统损害,其次是皮肤及其附件损害。大部分ADR患者经停药或对症治疗后均痊愈或好转。结论:应加强ADR监测力度,加强对特殊人群、静脉给药方式、抗菌药物和中药注射剂等重点药物的ADR监测,提高合理用药水平,减少药源性疾病的发生。
OBJECTIVE：To investigate the characteristics of the adverse drugs reactions（ADRs）in our hospital so as to pro-vide reference for clinical rational use of drugs. METHODS：225 ADR cases reported in our hospital during Sep. 2012-Sept. 2013 period,were analyzed retrospectively with regard to patients’age and gender,route of administration,drug types,ADR-involved organs or systems,clinical manifestation,severity and outcome of ADRs. RESULTS：The ADRs occurred mostly in females and in elderly patients over 60 years old and mostly via intravenous administration. The ADR-involved drugs were mainly antimicrobial drugs and traditional Chinese medicine preparations. The ADRs manifested mainly as gastrointestinal damage,followed by lesions of skin and its appendants,yet which were cured or recovered after drug discontinuation or symptomatic treatment. CONCLU-SIONS：We should strengthen the ADR monitoring in special group,during intravenous administration or when using such medi-cines as antimicrobial drugs and traditional Chinese medicine for injection in an effort to promote clinical rational use of drugs and reduce the incidences of drug-induced diseases.
出处
《中国医院用药评价与分析》
2014年第6期548-550,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
合理用药
抗菌药物
中药注射剂
ADR
Rational use of drugs
Antibiotics
Traditional Chinese medicine injection
