摘要
目的:了解江苏省东海县人民医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生的特点和规律,为合理用药提供参考。方法:对我院314例ADR报告的类型、患者的性别与年龄、引发ADR的给药途径及药物种类、ADR累及器官和(或)系统及主要临床表现、ADR转归及ADR的关联性评价等进行回顾性分析。结果:314例ADR报告中,一般的ADR 171例(占54.46%),严重的ADR 41例(占13.06%),新的、严重的ADR 102例(占32.48%);男性患者略多于女性;≤3岁者最多;静脉滴注引发ADR病例数最多,其次为口服给药和静脉注射。314例ADR报告共涉及11类药物86个品种,引发ADR病例数排序居前3位的分别为抗菌药物、中药制剂和神经系统用药;致ADR病例数排序居前3位的抗菌药物分别为头孢菌素类、大环内酯类和氟喹诺酮类。ADR主要累及皮肤及其附件,其次为消化系统和循环系统。ADR关联性评价中,"肯定"80例(占25.48%),"可能"52例(占16.56%),"很可能"182例(占57.96%)。所有患者均治愈或好转。结论:ADR的发生与多种因素相关,临床应提高ADR上报意识,加强用药监测;临床药师应积极参与临床治疗,促进合理用药。
OBJECTIVE： To investigate the characteristics and regularities of adverse drug reactions （ADR） in Jiangsu Donghai County People＇s Hospital （hereinafter referred to as ＂our hospital＂）, so as to provide reference for clinical rational drug application. METHODS： Retrospectively analysis was conducted on 314 cases of ADR reports in terms of types, patients＇ genders and ages, ADR-inducing administration routes and drugs, ADR involved organs and （or） systems and its main clinical features, ADR prognoses and the relevance evaluations of ADR. RESULTS ： Among the 314 reports of ADR, 171 cases were general ADR （54. 46% ）, 41 cases were severe ADR （ 13.06% ）, 102 cases were new and severe ADR （32.48%）; the number of male patients was slightly more than that of females; most patients aged ~〈 3; most ADR were induced by intravenous drip, the second was oral administration and intravenous injection. 86 kinds of 11 categories of drugs were involved in the 314 reports of ADR, the top 3 ADR-inducing drugs were respectively antibiotics, traditional Chinese medicine and drugs for nervous system; among reports of ADR induced by antibiotics, the top 3 were respectively cephalosporins, macrolides and fluoroquinolones. ADR mainly involved skin and its accessories, the second were digestive system and circulatory system. Of the relevance evaluations, 80 cases were ＂ definitely＂ （ 25.48% ）, 52 cases were ＂ possible＂ （ 16.56% ） , 182 cases were ＂probably＂ （57.96%）. All patients were cured or went better after treatment. CONCLUSIONS： The occurrence of ADR was related to various factors, ADR reporting and monitoring on medication should be reinforced; clinical pharmacists should take active participation in clinical treatment to promote rational medication.
出处
《中国医院用药评价与分析》
2017年第12期1711-1712,1716,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
分析
临床药师
合理用药
Adverse drug reactions
Analysis
Clinical pharmacists
Rational medication
