摘要
目的:观察自体外周血干细胞移植治疗乙型肝炎肝硬化失代偿期患者的疗效。方法:将58例乙型肝炎肝硬化失代偿期患者随机分为观察组38例和对照组20例。对照组予以基础治疗,观察组在基础治疗上行自体外周血干细胞移植治疗并随访24周,观察两组患者治疗前后血清白蛋白(ALB)、总胆红素(TBIL)、凝血酶原时间(PT)以及临床症状的变化。结果:对照组治疗后各时间段患者ALB、TBIL和PT水平与治疗前比较差异无统计学意义。与观察组治疗前比较,观察组患者治疗后12周和24周血清中ALB水平显著上升,TBIL和PT显著降低。观察组治疗后12周和24周各指标与对照组比较具有统计学差异。治疗8周后,对照组患者腹胀、食欲、乏困和腹水的改善率分别为50.00%、40.00%、55.00%和50.00%,观察组改善率分别为84.21%、78.95%、86.84%和92.00%,两组患者在腹胀、食欲、乏困和腹水的改善或减轻方面具有统计学差异。结论:自体外周血干细胞移植治疗失代偿期肝硬化安全、有效、副作用小,可作为肝硬化患者临床治疗方案。
Objective ：To observe the efficacy of autologous peripheral blood stem cell transplantation treating patients with decompensated hepatitis B liver cirrhosis .Methods ：58 patients with decompensated hepatitis B liver cirrhosis were randomly divided into observation group （n=38） and control group（n=20） .The control group were given basic treatment ,the observation group were treated with autologous peripheral blood stem cell transplantation and followed twentyfour weeks ,the changs of serum albumin（ALB） ,total bilirubin（TBIL） ,prothrombin time（PT ） and clinical symptoms were observed before and after treatment .Results ：The levels of ALB、TBIL and PT in control group after treatment had no statistical difference compared with protreatment .Comapred with protreatment ,the level of ALB in observation group increased significantly after treated twelve weeks and twentyfour weeks while the level of TBIL and PT decreased significantly .All indexes after treated twelve weeks and twentyfour weeks had statistical difference between contol group and observation group .The improved rate of bloating ,appetite ,fatigue and ascites were 50 .00% 、40 .00% 、55 .00% and 50 .00% respectively after treated for eight weeks ,the observation group were 84 .21% 、78 .95% 、86 .84% and 92 .00% respectively ,the two groups had statistical difference on the improvement of bloating ,appetite ,fatigue and ascites .Conclusion：Autologous peripheral blood stem cell transplantation treating for patients with decompensated hepatitis B liver cirrhosis is safe ,effective and has little side effects ,it can be used as clinical treatment for patients with hepatitis B liver cirrhosis .
出处
《陕西医学杂志》
CAS
2014年第7期790-792,共3页
Shaanxi Medical Journal
基金
陕西省科学技术研究发展计划项目(2012K16-08)
关键词
乙型肝炎/并发症
肝硬化/治疗
外周血干细胞移植/方法
移植
自体
Hepatitis/Complications
Liver cirrhosis/Therapy
Peripheral blood stem cell transplanta-tion/method
T ransplantation,autologous
