摘要
同种异体肝移植由于供体肝源缺乏、手术费用昂贵,操作要求高,术后免疫反应等原因限制了其在临床中的应用。随着生物细胞学及再生医学的发展,干细胞移植成为了医学领域中的研究热点,其中,自体骨髓干细胞移植在肝病治疗中的应用受到了更加广泛的关注。自体骨髓干细胞移植具有操作方法简单、可重复进行、创伤小、费用低、无免疫排斥反应等特点,并且已被动物模型与临床研究证实其治疗的有效性。文章对自体骨髓干细胞移植治疗终末期肝病的可行性及临床应用的研究进展进行综述。
The lack of donor liver,high surgery price,high operation requirements and postoperative immune response limit the clinical application of allogeneic liver transplantation.With the development of biological cytology and regenerative medicine,stem cell transplantation has become a popular topic in the medical research.Specially,research on autologous bone marrow stem cell transplantation in the treatment of liver disease has become more widespread.Autologous bone marrow stem cell transplantation has many advantages:it is easy to operate,repeatable,low-cost,and it brings small trauma and has no transplant rejection,etc.Moreover,its effectiveness of treatment has been confirmed by animal models and clinical studies.This review focuses on the research progress of the feasibility and clinical application of autologous bone marrow stem cells transplantation in the treatment of end-stage liver disease.
出处
《辽宁中医杂志》
CAS
2014年第7期1316-1318,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
哈尔滨市科技创新人才研究专项基金项目(RC2008xk003012)
关键词
自体骨髓干细胞移植
终末期肝病
综述
autologous bone marrow stem cells transplantation
end-stage liver disease
review
