摘要
不同的金属离子对兼性海洋霉菌黄柄曲霉 1 79的生长有不同的影响。在 0 0 0 2mol/L的浓度下 ,Hg2 +、Ag+和Cr3+能强烈抑制该菌的生长 ,Pb2 +、Sr2 +、Co2 +、Al3+对其生长有一定的抑制 ,生长量低于对照 ;Mn2 +、Ba2 +、Zn2 +对其生长没有明显影响 ;Cu2 +对该菌的生长有微弱的促进作用 ,菌体生物量略高于对照 ;不同的金属离子对曲霉 1 79抗真菌抗生素 1 79M合成有不同的影响。与对照相比 ,Ba2 +对其产量没有影响 ;Al3+、Zn2 +、Sr2 +有一定的抑制作用 ,其发酵相对效价分别为对照的 81 4%、 5 5 5 %和 6 5 %;0 0 0 2mol/L的Mn2 +和Pb2 +能强烈抑制此抗生素的合成 ,在添加 0 0 0 2mol/LMn2 +和Pb2 +的培养基中 ,虽然菌体生长良好 ,但无 1 79M产生 ;Co2 +和Cu2 +则有明显的促进作用 ,当培养基中添加0 0 0 2mol/L的Co2 +时其发酵相对效价提高到 2 6 1 4%;当培养基中添加 0 0 0 3mol/L的Cu2 +时其发酵相对效价提高到 3 5 0 2 %。Co2 +和Cu2 +对发酵的促进效应是相互拮抗的。
There were different effects of various metal irons on the growth of facultative marine mould Aspergillus flavipes strain 179 and the production of antifungal antibiotics terreic acid 179M. 0.002mol/L Hg 2+?Ag + and Cr 3+ can inhibit strongly the growth of the strain and Pb 2+?Sr 2+?Co 2+?Al 3+ also had depressing effects in some extent. While 0.002mol/L Cu 2+can stimulate its growth slightly. On the other hand, Al 3+?Zn 2+?Sr 2+ can inhibit the production of antifungal antibiotics terreic acid 179M with the relative potency 81.4%?55.5% and 65% respectively in comparison of the control. When adding 0.002mol/L Mn 2+ and Pb 2+ in the mediums, the strain can not synthesis the substance. Co 2+ and Cu 2+ can increase strongly the yields of 179M. When adding 0.002mol/L Co 2+, the relative potency of 179M increased to 261.45%; When adding 0.003mol/L Cu 2+, the relative potency of 179M increased to 350.25%.The stimulating effect of the two irons was antagonistic.
出处
《微生物学通报》
CAS
CSCD
北大核心
2002年第3期20-24,共5页
Microbiology China
基金
广东省自然科学基金资助项目 (No. 0 0 1 2 1 4 )
