摘要
目的了解人类免疫缺陷病毒(HIV)感染者/艾滋病(AIDS)患者合并乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染的流行情况和疾病特征。方法采用化学发光免疫测定法(CLIA)和酶联免疫吸附法(ELISA)检测血清标本中乙肝表面抗原本(HBsAg)、抗HCV和抗HIV指标,应用SPSS 16.0分析数据。结果共计收集1 038例HIV感染者/AIDS患者,其中单纯HIV感染者814例(78.4%),HIV-HBV感染者176例(17.0%),HIV-HCV感染者39例(3.7%),HIV-HBV-HCV感染者9例(0.9%)。天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和传播途径在单纯HIV组、HIV-HBV和HIV-HCV(含HIV-HBV-HCV)3组间的分布差异有统计学意义(P<0.05),其中AST异常率在HIV-HBV(33.9%)、HIV-HCV组(34.0%)均较HIV组(15.0%)高,ALT异常率以合并HBV组(38.3%)较高,指标差异性主要体现在男性人群中。HIV-HCV组以静脉注射与血液传播途径较高(54.2%),异性性传播次之(39.6%);HIV和HIV-HBV组以异性性传播途径较高(67.7%、71.0%),同性性传播次之(30.7%、23.9%)。结论 HIV-HBV/HCV合并感染应引起重视,疫苗被认为是行之有效的控制HBV合并感染的有效措施,然而在现有防控体系下,应进一步强化针对传播途径的控制措施。
[Objective]T o explore the epidemic situation and disease characteristics human immunodeficiency virus(HIV)infections/AIDS patients co-infected with hepatitis B virus(HBV) and hepatitis C virus(HCV).[Methods]The chemiluminescence immunoassay assay(CLI A) and enzyme linked immunosorbent assay(ELISA) were used to detect the indexes of HBs Ag,anti-HCV and anti-HIV,and the data were analyzed by SPSS 16.0.[Results]A total of 1 038 HIV infections/AIDS patients were collected,including 814(78.4%) cases of single HIV infection,176(17%) cases of HIV-HBV co-infection,39(3.7%) HIV-HCV co-infection, and 9( 0. 9 %) case s of HIV-HBV-HCV co-infection. There were statistically significant differences in levels of aspartate aminotransferase(AST) and alanine aminotransferase(ALT) and route of transmission among HIV,HIV-HBV,and HIV-HCV groups(including HIV-HBV-HCV)(P<0.05). The abnormal rate of AST in HIV-HBV group(33.9%) and HIV-HCV group(34%)was higher than that in HIV group(15%). The abnormal rate of ALT in HIV-HBV group was the highest(38.3%). And the difference of the AST and ALT mostly existed in the male population. Most of the HIV-HCV infection cases were transmitted by the vein injection and blood(54.2%),followed by the heterosexual transmission(39.6%). Most of the HIV cases and HIV-HBV cases were transmitted by heterosexual transmission(67.7%,71.0%), followed by the homosexual transmission(30.7%,23.9%).[Conclusion]It should be paid more attention to the coinfection of HIV-HBV/HCV. Under the prevention and control system nowaday,the prevention and control measures related to the transmission route need be strengthened,though the vaccine is recorded as the best useful control measure of HBV co-infection.
作者
胡茂红
孙华宝
冯长华
胡塔
路亮
徐丹
周显凤
HU Mao-hong;SUN Hua-bao;FENG Chang-hua;HU Ta;LU Liang;XU Dan;ZHOU Xian-feng(AIDS and STD Prevention and Control Department,Nanchang Center for Disease Control and Prevention,Nanchang Jiangxi, 330038,China;Second Department of lnfectious Disease,Ninth Hospital of Nanchang City,Nanchang Jiangxi,330062,China)
出处
《职业与健康》
CAS
2019年第2期213-217,共5页
Occupation and Health
基金
日本学术振兴会论文博士奖学金项目(JSPS RONPAKU Program R11619)
关键词
人类免疫缺陷病毒
乙型肝炎病毒
丙型肝炎病毒
临床特征
合并感染
Human immunodeficiency virus
Hepatitis B virus
Hepatitis C virus
Clinical characterization
Co-infection
