摘要
近年来脂肪酸代谢与肿瘤间的关系成为研究热点。在肿瘤细胞中,脂肪酸代谢对其生长及转移具有重要意义。在合成方面,脂肪酸可参与癌细胞膜上磷脂的结构合成与重要信号的转导(如PI3K-AKT-mTOR);在分解方面,癌细胞主要利用脂肪酸β-氧化产生的ATP来维持所需的能量,以及利用烟酰胺腺嘌呤二核苷酸磷酸(NADPH)来维持体内的氧化还原平衡。因此,脂肪酸的合成和分解可能对肿瘤的发生和发展具有重要作用,但是其中的机制仍不清楚。文章对脂肪酸代谢在促进肿瘤发生、发展和转移方面的影响进行综述。
In recent years, the relationship between fatty acid metabolism and tumor has become a hot topic and widely recognized. In tumor cell, fatty acid metabolism is important to its growth and metastasis. About synthesis, fatty acid can participate in the synthesis of phospholipids on the membrane of cancer cells and take part in important signal transduction pathways, such as PI3K-AKT-mTOR;in fatty acid catabolism, tumor cells can produce ATP to maintain its growth by β-oxidation;what's more, it could be kept redox homeostasis by producing nicotinamide adenine dinucleotide phosphate hydrogen (NADPH). So, anabolism and catabolism of fatty acid may promote occurrence and development of tumors, but the mechanisms are unclear. This review highlights the effects of fatty acid metabolism on the occurrence, development and metastasis of tumors.
作者
黄威
程忠平
Huang Wei;Cheng Zhongping(Department of Gynecology and Obstetrics, Yangpu District Central Hospital Affiliated to Tongji University, Shanghai 200090, China;Department of Gynecology and Obstetrics, Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China)
出处
《肿瘤研究与临床》
CAS
2018年第12期879-882,共4页
Cancer Research and Clinic
基金
上海市重点专科建设项目 (ZA2015A33).
关键词
肿瘤转移
肿瘤发生
肿瘤发展
脂肪酸合成
脂肪酸分解
Neoplasm metastasis
Neoplasm occurrence
Neoplasm development
Fatty acid synthesis
Fatty acid decomposition
