摘要
斯钙素2是一种分泌型糖蛋白激素,在多种人类恶性肿瘤中表达升高。斯钙素2通过多条信号传导通路参与肿瘤增殖、凋亡、侵袭转移、缺氧耐受和化疗耐药等诸多生物学事件的调控,提示其可能是肿瘤分子调控网络中的一处重要节点。深入阐述斯钙素2在肿瘤中的作用机制,有望为肿瘤的临床诊疗提供一个新的分子标志物和治疗靶点。
Stanniocalcin 2,a secreted glycoprotein hormone,has been found to be highly expressed in a variety of human malignancies.Through several signal transdution pathways,stanniocalcin 2 plays important roles in the regulation of many biological events of tumor such as proliferation,apoptosis,invasion and metastasis,hypoxia tolerating and drug resistance,indicating stanniocalcin 2 may be a pivotal node in the molecular regulation network of tumor.Stanniocalcin 2 is expected to become a novel biomarker and therapeutic target for diagnosis and treatment of tumor if the funtional mechanisms of stanniocalcin 2 could be further elaborated.
作者
余计赏
吴帆
Yu Jishang;Wu Fan(Department of General Surgery,Guangzhou Red Cross Hospital,Medical College,Jinan University,Guangzhou 510220,China)
出处
《国际肿瘤学杂志》
CAS
2018年第10期615-618,共4页
Journal of International Oncology
基金
国家自然科学基金(81000989)
广东省医学科研基金(A2017517)
广州市卫生计生科技项目(20171A011250).
关键词
肿瘤
细胞增殖
细胞凋亡
肿瘤转移
斯钙素2
Neosplasms
Cell proliferation
Apoptosis
Neoplasm metastasis
Stanniocalcin 2
