摘要
目的分析炎性肠病患者病原学以及其菌群变化与内皮细胞黏附分子-1(ICAM-1)、C反应蛋白(CRP)与菌群数目间的相关性,为炎性肠病患者的临床治疗提供参考。方法选择2015年5月—2018年5月武警四川省总队医院消化内科收治炎性肠病活动期患者158例作为研究对象,并根据疾病类型分为2组,克罗恩病(CD组42例)和溃疡性肠炎(UC组116例);另选取同期来医院体检的健康人48例作为对照组。入院时,采取2组人员新鲜粪便进行肠道菌群培养,并检测血清ICAM-1、CRP水平,分析炎性肠病患者ICAM-1、CRP与菌群数目间的相关性。结果 UC组患者的肠球菌属、酵母菌属、拟杆菌、双歧杆菌、乳杆菌属、小梭菌、肠杆菌属的数目明显多于对照组,真杆菌数目明显少于对照组(t/P=39. 903/0. 000,4. 948/0. 000,31. 525/0. 001,17. 338/0. 000,9. 983/0. 000,6. 798/0. 000,10. 960/0. 000,2. 022/0. 024,11. 053/0. 000); CD组患者的肠球菌属、酵母菌属、拟杆菌、双歧杆菌、消化球菌、乳杆菌属、肠杆菌属的数目明显多于对照组,小梭菌、真杆菌的数目明显少于对照组(t/P=39. 369/0. 000,13. 200/0. 000,14. 040/0. 000,7. 386/0. 000,9. 453/0. 000,4. 899/0. 000,9. 598/0. 000,6. 060/0. 000,12. 207/0. 000)。UC组患者的拟杆菌、双歧杆菌、消化球菌、小梭菌的阳性检出率明显高于对照组(χ~2/P=4. 497/0. 034,6. 470/0. 011,5. 738/0. 017,4. 641/0. 031); CD组患者的酵母菌属、双歧杆菌的阳性检出率明显高于对照组,而真杆菌的阳性检出率明显低于对照组(χ~2/P=4. 100/0. 043,4. 091/0. 043,4. 464/0. 035)。UC组和CD组患者的ICAM-1、CRP水平均明显高于对照组(t/P=15. 204/0. 000,24. 304/0. 000,19. 148/0. 000,23. 650/0. 000)。UC组患者的ICAM-1、CRP水平与其肠球菌属、双歧杆菌、肠杆菌属呈负相关(r/P=-0. 584/0. 000,-0. 682/0. 000,-0. 651/0. 000,-0. 543/0. 000,-0. 587/0. 000,-0. 702/0. 000)。结论炎性肠病患者的血清CRP、ICAM-1水平与其肠球
Objective To analyze the correlation between the etiology of inflammatory bowel disease and the changes of bacterial flora with ICAM-1,CRP and the number of bacterial flora,so as to provide reference for clinical treatment of inflammatory bowel disease. Methods From May 2015 to May 2018,158 patients with inflammatory bowel disease in the active stage of digestion and internal medicine department of Armed police Sichuan General Hospital were selected as the study subjects,and were divided into two groups according to the type of disease,Crohn’s disease (42 cases in CD group) and ulcerative enteritis (116 cases in UC group),and 48 healthy people who came to the hospital for physical examination during the same period were selected as the control group. At admission,intestinal flora was cultured in fresh feces of two groups,and serum ICAM-1 and CRP levels were detected to analyze the correlation between ICAM-1,CRP and the number of bacteria flora in patients with inflammatory bowel disease. Results The number of enterococcus,yeast,bacteroides,bifidobacteria,lactobacillus,Clostridium and Enterobacter in UC group was significantly higher than that in control group,and the number of true bacteria was significantly less than that in control group (t/P = 39. 903/0. 000,t/P = 4. 948/0. 000,t/P = 31. 525/0. 001,t/P = 17. 338/0. 000,t/P = 9. 983/0. 000,t/P = 6. 798/0. 000,t/P = 10. 960/0. 000,t/P = 2. 022/0. 024,t/P = 11. 053/0. 000).The number of enterococcus,yeast,bacteroides,bifidobacteria,digestive coccus,Lactobacillus and enterobacteria in CD group was significantly higher than that in control group,and the number of Clostridium minor and Eubacterium was significantly less than that in control group (t/P = 39. 369/0. 000,t/P = 13. 200/0. 000,t/P = 14. 040/0. 000,t/P = 7. 386/0. 000,t/P = 9. 453/0. 000,t/P = 4. 899/0. 000,t/P = 9. 598/0. 000,t/P = 6. 060/0. 000,t/P = 12. 207/0. 000). The positive detection rates of bacteroides,bifidobacteria,digestive cocci and Clostridium parvum in UC group were significantly higher
作者
曾凡清
王月兴
苟晓盼
邓丽娟
ZENG Fanqing;WANG Yuexing;GOU Xiaowang;DENG Lijuan(Department of Gastroenterology,Armed Police Sichuan General Hospital,Leshan 514000,China)
出处
《疑难病杂志》
CAS
2018年第12期1333-1337,共5页
Chinese Journal of Difficult and Complicated Cases
