摘要
目的 研究急性脑出血 (ACH)后脑脊液〈CSF〉中IL -6和CRP的变化与急性脑血管损伤程度的关系。方法 采用ELISA和透射免疫比浊法分别测定 2 0例对照组、15例脑出血患者CSF中IL -6和CRP含量 ,并分析IL -6和CRP的相关性。结果 对照组、脑出血IL -6含量分别为 2 3 .33± 10 .73、42 7.0 3± 5 96 .31pg/ml;CRP含量分别为 1.46± 0 .47、1.39± 0 .5 8ng/ml;脑出血患者IL -6明显高于对照组 (Z =4.90 ,P <0 .0 1) ,而CRP无明显变化 (t =0 .6 3 ,P >0 .0 5 ) ;脑室出血者IL -6 (n =7,839.13± 6 12 .33pg/ml)较无脑室出血者 (n =8,2 12 .85± 2 0 1.82pg/ml)显著增高 (Z =3 .2 4,P <0 .0 1)。结论 脑出血急性期CSF中IL -6显著升高 ,应是脑组织局部合成和分泌所致 ,并与脑损伤程度有关。
Objectives To study the relation between the varieties of Inferleukin-6 (IL-6) and C-reactive protein(CRP) in Acute Cerebral Hemorrhage suffers' cerebrospinal fluid(CSF)and the degree of acute cerebral vessel injury. Methods Tested the level of IL-6 and CRP in the CSF of 20 non-ACH patients and 15 ACH patients by ELISA and Turbidimetry Immunoassay, and analysesed the relations. Results The level of IL-6 in CSF of contrast team and ACH team is 23.33 ±10.73pg/ml,423.03±596.3pg/ml; the level of CRP in CSF of them is 1.46±0.47ng/ml, 1.39±0.58pg/ml. The level of IL-6 in CSF of ACH team is higher than of contrast team considerably (Z=4.90,P<0.01),but there isn't much difference between the level of CRP of them (t=0.67,P>0.005).The level of IL-6 in CSF of cerebral ventricles Hemorrhage patients(n=7,839.13±612.33pg/ml)is much higher than of non-Cerebral Ventricles Hemorrhage patients(n=8,212.85±201.82pg/ml),(Z=3.24,P<0.01). Conclusions It should be the results of local encephalic tissue composing and secreting that the level of IL-6 of CSF in ACH patient increase notably, and related with the degree of Cerebral Injury.
出处
《中国实验诊断学》
2001年第4期163-164,共2页
Chinese Journal of Laboratory Diagnosis
关键词
脑出血
白细胞介素6
C反应蛋白
Cerebral Hemorrhage
Inferleukin-6
Cerebrospinal Fluid
