摘要
目的探讨白细胞介素!6(IL!6)在吉兰!巴雷综合征(Guillian!Barre Syndrome,GBS)发病及诊断中的作用。方法采用ELISA法测定GBS患者急性期和恢复期脑脊液中IL!6水平,并与正常人脑脊液对照。结果36例成人GBS患者脑脊液IL!6水平为(36.88±9.26)×1012kU/L;26例正常对照组为(14.97±8.68)×1012kU/L;成人GBS组脑脊液IL!6水平明显高于正常对照组,P<0.01。18例成人GBS患者脑脊液IL!6治疗前水平为(33.57±5.0)×1012kU/L,治疗后水平为(13.55±8.03)×1012kU/L,较治疗前明显下降(P<0.01)。但病情轻重各级之间脑脊液IL!6水平无显著性差异。结论IL!6参与GBS的病理过程,但与病情轻重无明显关系。
Objective To study the effect of interleukin-6 （IL-6） in the pathogenesis and dignosis of Guillian- Barre syndrome（GBS）. Methods IL-6 in cerebrospinal fluid （CSF） from 36 patients with GBS and 26 normal persons by using ELISA were measured. Results IL-6 was （36.88± 9.26） × 10^12kU/L, （14.97 ± 8.68） × 10^12kU/L in CFS from 36 GBS patients and 26 normal persons respectively. The level of IL-6 in GBS group was higher than that in normal group （P 〈 0.01）. The level of IL-6 in CSF of 18 adult GBS patients was （33.57 ± 5.0）× 10^12kU/L, which was higher than that after treatment （ 13.55 ± 8.03 ） × 10^12kU/L（P 〈 0.01 ）, but the levels of IL-6 in defferent disease severity has no significant difference（P 〉 0.05 ）. Conclusions IL-6 may be involved in the pathologic process of GBS. More study is needed to further understand the pathogenesis, early diagnosis and treatment of GBS.
出处
《北京医学》
CAS
2005年第10期609-611,共3页
Beijing Medical Journal
