摘要
目的 :研究癌基因和抑癌基因蛋白产物在膀胱移行细胞癌组织中异常表达与肿瘤病理分级和临床分期之间的关系。方法 :应用免疫组织化学方法检测 96例膀胱移行细胞癌标本中 P5 3、C- erb B- 2和 bcl- 2基因的表达水平。结果 :96例膀胱移行细胞癌标本中 P5 3、C- erb B- 2、bcl- 2基因的阳性表达率分别为 60 .4 %、66.7%和81.3 % ;P5 3、C- erb B- 2和 bcl- 2异常表达与膀胱癌的病理分级和临床分期之间的差异有统计学意义 ( P<0 .0 1)。结论 :P5 3、C- erb B- 2和 bcl- 2基因异常表达在膀胱癌发生发展中起重要作用 ,肿瘤的多基因分析比单基因分析更有价值 ,为临床病理诊断及估计预后和复发提供了参考指标。
Purpose:To study the correlation of oncogene and antioncogene protein expression in transitional cell carcinoma of the urinary bladder and their significances to histopathological grading and clinical staging of this cancer.Methods:The immunohistochemical staining was used to evaluate the expression of P53?CerbB2?bcl2 in 96 cases of transitional cell carcinoma of the bladder.Results:The positive rate of three expression products was 60.4 % (P53), 66.7 % (CerbB2), 81.3 % (bcl2). The expression products of P53?CerbB2 and bcl2 were found to be positively correlated with the degree of differentiation and the clinical staging of this tumor.Conclusions:The results suggested that these oncogene proteins play important roles in occurrence and development of the transitional cell carcinoma of the bladder. These findings suggest that the detection of multiple oncogenes and antioncoegnes is more valuable than that of single oncogene or single antioncogene. Multiple oncogene proteins are assayed for help to pathological diagnosis, prognosis and recurrence.
出处
《临床泌尿外科杂志》
2001年第8期368-370,共3页
Journal of Clinical Urology
关键词
膀胱肿瘤
癌基因
免疫组织化学
Bladder neoplasms
Carcinoma genes
Immunohistochemistry
