摘要
[目的]研究p16、p53、C erbB 2蛋白的表达与胃癌临床病理学特征的关系。[方法]应用免疫组织化学方法研究100例胃癌组织中 ,p16、p53、C erbB 2蛋白的表达 ,并进行增殖细胞核抗原 (PCNA)检测。[结果]100例胃癌中p16、p53、C erbB 2的阳性率分别为43 %、56%和50%。p53、C erbB 2阳性表达 ,p16阴性表达的患者预后差 (P值分别<0.01和<0.05) ,p53表达与细胞增殖、病理分型、分化程度有密切关系 ,C erbB 2表达与淋巴结转移、浸润深度相关。[结论]多基因分析比单基因分析更有价值 ,p16、p53、C erbB 2蛋白异常表达及其相互作用在胃癌发生、发展中起重要作用 。
To approach the relationship of p16,p53,C erbB 2 expression with the clinicopathological characteristics of gastric cancer.p16,p53,C erbB 2 and proliferating cell nuclear antigen( PCNA ) expressions of 100 cases of gastric cancer tissues were investigated by immunohistochemical method. Of 100 cases with gastric cancer,positive expression rates of p16,p53 and C erbB 2 were 43%, 56% and 50%,respectively.p53,C erbB 2 positive expression and p16 negative expressions indicated bad prognosis (P<0.01 and<0.05). p53 positive expression was closely related to cell proliferation,pathological types and differential degree .C erbB 2 postive expression was correlated to lymph node metastasis and infiltration degree.The protein expression mentioned above occurred in 83% of gastric cancer,the multiple protein expressioned simultaneously in 47%.[Conclusions] The analysis of multi gene is more valuable than that of single gene.The abnormal expressions of p16,p53 and C erbB 2 and their mutual actions play an important role in gastric carcinogenesis.These protein expressions are effective indicators for prognosis of gastric cancer.
出处
《肿瘤学杂志》
CAS
2001年第4期208-210,共3页
Journal of Chinese Oncology
基金
绍兴市医药卫生科技计划项目
关键词
P53蛋白
C-ERBB-2蛋白
增殖细胞核抗原
免疫组织化学
胃癌
stomach neoplasmas
protein, p16
protein,p53
protein,C-erbB-2
proliferating cell nuclear antigen
immunohistochemistry
