摘要
目的 :探讨血浆降钙素基因相关肽 (CGRP)和内皮素 (ET)与高血压病之间关系。方法 :放射免疫方法检测 2 5例正常人和 36例高血压病患者降压治疗前后血浆 CGRP和 ET浓度 ,同时测量高血压病患者血压。结果 :1高血压病患者血浆 CGRP浓度低于正常人 ,与平均动脉压呈负相关 ;ET浓度高于正常人 ,与平均动脉压呈正相关。2有效降压治疗后 ,高血压病患者血浆 CGRP浓度回升 ,ET浓度下降 ,CGRP/ ET比值明显升高。结论 :血浆 CGRP和ET浓度失衡可能是高血压病发生的重要原因之一 ;有效降血压可能与 CGRP和 ET的变化有关。
AIM:To investingate the relationship between the plasma calcitonin gene related peptide (CGRP),endothelin (ET) in patient with essential hypertension. METHODS:We determined the plasma concentration of CGRP and ET in 25 normotension people and 36 patients with essential hypertension before and after anti hypertension treatment with radioimmunoassay,and measured the blood pressure of essential hypertension patients. RESULTS:①The plasma CGRP concentration in patients with essential hypertension was lower than that in the normotension people,and there was a negative relationship between it and the mean artery pressure. The plasma ET concentration in patients with essential hypertension was higher than that in the normotension people, and there was a positive relationship between it and the mean artery pressure. ②After effective antihypertension treatment,the plasma CGRP concentration in the hypertensive was elevated,the plasma ET concentration was lowered,and the rate of CGRP/ET was elevated. CONCLUSION:The unbalance between plasma CGRP and ET concentration might be an important reason for essential hypertension,and the effective antihypertension treatment might regulate the balance between this pair of vasoactive substances.
出处
《心脏杂志》
CAS
2001年第3期188-189,192,共3页
Chinese Heart Journal
关键词
高血压
降钙素
基因相关肽
内皮素
hypertension
calcitonin
gene related peptide,endothelin
