摘要
目的:研究吴茱萸次碱对离体大鼠室颤阈的影响。方法:离体心脏采用Langendorff恒流灌流,分别予溶媒、低剂量吴茱萸、高剂量吴茱萸处理5min并记录处理前后心率,采用S1S2法测量有效不应期,采用串刺激法测量室颤阈。结果:与溶媒组相比,低剂量组、高剂量组的有效不应期和室颤阈均无显著性差异。结论:吴茱萸次碱对离体大鼠室颤阈没有明显的影响。
Objective :To investigate the effect of rutaecarpine on the ventricular fibrillation threshold (VFT) of isolated rat heart. Method : The isolated rat hearts were mounted on a Langendorff perfusion apparatus with constant flow. 24 isolated rat hearts were divided into three groups, treated with vehicle, low dose rutaecarpine, high dose rutaecarpine for 5 minutes, respectively. Heart rates before and after treatment were recorded , the effective refractory period (ERP) was measured by S1S2 stimulate, the VFT was measured by tetanic stimulation. Result : the VFT and ERP of low dose rutaecarpine group and high dose rutaecarpine group had no significant difference from that of vehicle group. Conclusion : Rutaecarpine has no effect on the VFT of isolated rat heart.
出处
《中华中医药学刊》
CAS
2008年第1期48-50,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
吴茱萸次碱
大鼠
室颤阈
有效不应期
rutaecarpine
rat
ventricular fibrillation threshold
effective refractory period