摘要
目的 :研究血管紧张素Ⅰ转化酶 (ACE)基因插入 /缺失 (I/D)多态和中国汉族 2型糖尿病患者视网膜病变 (DR)的相关性。方法 :用PCR技术检测 10 2例 2型糖尿病患者ACE基因I/D多态基因型。结果 :DR组与无DR组、病程 <5年合并DR者 (n =10 )与病程 >5年无DR者 (n =19)相比 ,D型等位基因和DD基因型的频率均无显著增高 (P >0 .0 5)。但增生DR组 (n =17)较单纯DR组 (n =2 0 )D型等位基因和DD基因型的频率增高 (χ2 分别为 6 15、4 38,P <0 .0 5)。结论 :ACE基因I/D多态与 2型糖尿病视网膜病变无相关性 ,与某些患者早期发展为DR无关 ,与增生性视网膜病变有关。
Objective:To study the association between an insertion/deletion(I/D) polymorphism of angiotensin I converting enzyme(ACE) gene and diabetic retinopathy(DR) in the patients with Chinese type 2 diabetes.Methods:PCR technique was used to determine the ACE gene polymorphism in Chinese type 2 diabetics with retinopathy(n=37) and without retinopathy(n=46).Results:There were no differences in D type allele and DD genotype between DR and non retinopathy group(χ 2 was 2.23,2.59 respectively,P>0.05).D type allele and DD genotype distribution were also not prevalent in retinopathy patients with short duration(n=10) than those in non retinopathy patients with long duration(n=19,χ 2 was 3.42,1.90 respectively,P>0.05).But D type allele and DD genotype in proliferative group were higher than those in simple retinopathy group(χ 2 was 6.15,4.38 respectively,P<0.05).Conclusion:It is suggested that simple retinopathy patients carrying D type allele are prior to proliferative pathological changes.It is available to determine ACE gene genotype in simple retinopathy patients for early prognosis and treatment of proliferative retinopathy.
出处
《山东医科大学学报》
2001年第2期112-113,118,共3页
Acta Academiae Medicinae Shandong
基金
山东省科委资助课题 ( 1999BB1CJA2 )
关键词
Ⅱ型糖尿病
视网膜病变
血管紧张素Ⅰ转化酶
基因多态性
Gene,polymorphism
Angiotensin I convertase
Diabetes mellitus,non insulin dependent
Retinal diseases
