摘要
目的探讨血管紧张素转化酶基因I／D（ACEL／D）多态性与白癜风的关系。方法检索PubMed、CochraneLibrary、中国学术期刊全文数据库、维普数据库和万方数据库，按纳入、排除标准纳入研究，评价纳入研究质量，并采用Stata12．0进行定量分析。结果最终纳入9篇病例对照研究。Meta分析结果显示，总人群的ACEI／D中基因型（DD＋II）VS．DI（OR=0．759，95％CI：0．643～0．896，P：0．001），（DD＋DI）VS．II（OR=1．523，95％CI：1．153～2．011，P=0．003）与白癜风易感性之间有相关性。亚组分析显示，亚洲人中基因型DVS．I（OR=1．381，95％C1：1．054—1．810，P=0．019）；DDVS．II（OR=1．830，95％：1．110～3．017，P=0．018）；（DD＋II）VS．DI（OR=0．814，95％C1：0．667～0．994，P=0．043）；（DD＋ID）VS．II（OR=1．690，95％CI：1．147～2．489，P：0．008）；与白癜风发生有关。阿拉伯人群基因型（DD＋II）VS．DI（OR=0．545，95％C1：0．354～0．840，P=0．006）与白癜风发生有关。通过Begg’S检验判断发表偏倚，所有基因类型均不存在任何发表偏倚。结论ACEI／D基因多态性可能与白癜风易感性有关。
Objective To investigate the relationship of angiotensin converting enzyme （ ACE I/D） gene LiD polymorphism with vitiligo. Methods PubMed, the Cochranc Library, China academic journal full-text database and VIP database and Wan fang database were searched according to the inclusion and ex- clusion criteria, and the quality of included studies was assessed. The data were quantitatively analyzed by Stata 12. 0 software. Results Nine articles were included. Meta analysis results showed that the suscepti- bility of vitiligo difference was statistically significant in the total population of ACE LiD genotype （DD ＋ II） vs. DI （OR=0.759, 95% CI： 0.643 -0.896, P：0.001）, the （DD＋DI） vs. II （OR=1.523, 95% CI： 1. 153 -2. 011, P =0. 003）. The genotype subgroup analysis showed the D vs. I （OR = 1. 381, 95% CI： 1. 054 -1. 810,P=0. 019） , DDvs. II （OR=1.830, 95% CI：1.110-3.017, P=0.018）, （DD＋ lI） vs. DI （ OR = 0. 814, 95% CI：O. 667 - 0. 994, P = 0. 043）, and the （ DD ＋ ID） vs. II （ OR = 1. 690, 95% CI： 1. 147 - 2. 489, P =0. 008） in Asian. The difference was statistically significantly related to viti- ligo. Arab genotype （ DD ＋ II） vs. DI （ OR =0. 545, 95% CI：O. 354 - 0. 840, P =0. 006） was associated with vitiligo occurrence. Begg＇s inspection publication bias analysis showed all genetic types did not exist any publication bias. Conclusions The ACE gene I/D polymorphism may be associated with vitiligo sus- ceptibility.
出处
《中国医师杂志》
CAS
2017年第4期538-541,共4页
Journal of Chinese Physician
