摘要
采用meta分析系统评价中国汉族人血管紧张素转换酶(ACE)基因缺失(DD)多态性与2型糖尿病视网膜病变的关系。共纳入16篇符合条件的文献,共计2型糖尿病视网膜病变组1014例,对照组1135例。结果显示OR为1.69(95%CI 1.19~2.40),合并统计值z=2.91(P=0.004)。汉族人群ACE基因该多态性与糖尿病视网膜病变有关联,糖尿病视网膜病变组DD基因型增多。
To clarify the relationship between angiotensin converting enzyme (ACE) gene insertion/ deletion (I/D) polymorphism and diabetic retinopathy in type 2 diabetic patients by meta analysis. 16 eligible articles were selected in this study, including 1 014 patients with diabetic retinopathy and 1 135 controls. The meta analysis revealed that systematic data Z=2.91 ( P=0. 004) , OR= 1.69(95% CI 1.19-2.40). There is association between ACE gene I/D polymorphism and the diabetic retinopathy in type 2 diabetic patients.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2010年第8期679-681,共3页
Chinese Journal of Endocrinology and Metabolism
基金
成都医学院创新实验项目(2009154)