摘要
目的 :前瞻性地探讨血管紧张素转换酶 (ACE)基因插入 /缺失 (I/D)多态性与 2型糖尿病视网膜病变(DR)的关系。方法 :应用PCR方法检测 72名无DR的 2型糖尿病患者 ,同时测定体重指数 (BMI)、平均动脉压(MAP)、空腹血糖 (FBG)、血肌酐 (Scr)、糖化血红蛋白 (HbA1c) ;在严格控制血糖、血压的情况下随访 6年 ,每 1～ 2年复查一次眼底 ,血肌酐、BMI及HbA1c。结果 :72例受试者退出 7例 ,退出率为 9.7% ;ACEII ,ID ,DD 3种基因型在入组和终点时各临床参数 (BMI ,MAP ,FBG ,Scr,HbA1c)差异无显著性 (P >0 .0 5 ) ;到达终点时 ,各组背景型DR(II4 2 .9% ,ID 4 7.8% ,DD 4 2 .9% )、增殖型DR(II 2 5 .0 % ,ID 2 1 .7% ,DD 2 1 .4 % )及DR总发生率 (II 6 7.9% ,ID6 9.6 % ,DD 6 4 .3% )差异无统计学意义 (P >0 .0 5 )。结论 :ACE基因I/D多态性与中国汉族 2型糖尿病病人DR的发生和发展无关联。
Objective To prospectively clarify the relationship between angiotensin converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism and diabetic retinopathy (DR) in Type 2 diabetic patients.Methods A 6 year prospectively study was designed to investigate the change of retina of 72 Type 2 diabetic patients without retinopathy .All patients suffered from diabetes mellitus for more than 5 years and matched well in age,body mass index(BMI),mean arterial pressure(MAP),and fasting blood glucose (FBG). Patients were classified into 3 groups according to their genotypes of ACE. ACE gene I/D polymorphism was identified by polymerase chain reaction.The patients were followed up for 6 years and their BMI,serum creatinine (Scr),MAP,HbA1c,and retina were checked once every 1～2 years.Results Seven subjects (9.7%) were discontinued prematurely. At the end of the study, there were no significant differences in the clinical parameters such as BMI,MAP,FBG,HbA1c,and Scr among the 3 groups ( P >0.05), and also in DR incidence in Type 2 diabetic patients among the 3 groups (II 67.9%,ID 69.6% ,DD 64.3% ,respectively, P >0.05 ).Conclusion There is no association between ACE gene I/D polymorphism and the genesis and development of DR in Type 2 diabetic patients.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第4期410-413,共4页
Journal of Central South University ：Medical Science
基金
湖南省卫生厅基金课题 (2 0 0 1 Y2 4 )
