摘要
目的 :探讨内皮素 (ET)及氧自由基 (OFR)在急性胰腺炎 (AP)发病中的作用及相互关系。方法 :采用放射免疫分析法、硫代巴比妥酸法及黄嘌呤氧化酶法测定 17例重症急性胰腺炎 (SAP)、3 5例轻症急性胰腺炎 (MAP)及 3 0例正常对照 (NC)组血浆 ET、血清丙二醛 (MDA)及超氧化物歧化酶 (SOD)的含量。结果 :SAP患者 ET显著增高 ,MAP患者 ET明显降低 ,两组比较具有显著差异 (P<0 .0 0 1)。 AP患者 MDA显著增高 ,而 SOD明显降低。 SAP与 MAP两组患者 MDA比较具有显著差异 (P<0 .0 0 1) ,而两组患者 SOD比较无显著差异 (P>0 .0 5 )。结论 :OFR损伤是 AP发病的重要因素之一。本文提示 ,ET水平增高协同 OFR参与 SAP发病机制 ,ET水平降低对 MAP胰腺组织可能具有一定的保护作用。
Purpose: To explore the effects and relationship between endothelin(ET) and oxygen free radical(OFR) in the pathogenesis of acute pancreatitis (AP). Methods: The contents of plasma ET, serum malondialdehyde(MDA) and super oxide dismutase(SOD) were measured by the methods of analysis of radioimmunoassay, thiobarbiturate and xanthinoxidase in the blood samples from 17 patients with severe acute pancreatitis(SAP), 35 patients with mild acute pancreatitis(MAP) and 30 normal controls(NC). Results: The levels of ET increased significantly in SAP, while the levels of ET decreased obviously in MAP. There was significent difference(P<0.001) between the levels of ET in SAP and those in MAP. The levels of MDA increased significantly, while the levels of SOD decreased obviously in AP. The levels of MDA appeared significant difference(P<0.001) in SAP compared with MAP, while the levels of SOD had no significant difference in MAP and SAP. Conclusion: OFR injury one of the importance factor in the pathogenesis of AP. The increased levels of ET take part in the pathogenesis of SAP together with the former. The decreased levels of ET may be have the function of protecting pancreatic tissue against injury in AP.
出处
《临床消化病杂志》
2001年第2期77-79,共3页
Chinese Journal of Clinical Gastroenterology
关键词
急性胰腺炎
内皮素
氧自由基
Acute pancreatitis Endothelin Oxygen free radical
