摘要
胰胆管内逆行注射 5 .0 %牛磺胆酸钠溶液 ,建立大鼠急性出血坏死性胰腺炎 (AHNP)模型 ,通过光镜普通染色、PTH染色及电镜超微结构方法 ,对诱导AHNP后 5min至 6h胰腺的病变及微循环的形态学表现进行观察 ,以探讨胰腺炎的病因和发病机制。发现 :诱导AHNP后主要病变为 :胰腺组织出血、坏死 ,白色血栓、微血栓及混合血栓形成 ;并且随着诱导时间的延长病变加重。提示
Observations of pathologic morphology were made at the early phase of acute hemorrhagic and necrotic pancreatitis(AHNP), to investigate pathogenesis of acute pancreatitis. AHNP was induced in rats(30, weight 300～350 g) by intraductal administration of 5% sodium taurocholate. The pathologic morphologic changes of pancreatic tissue were examined by light microscope by HE and PTH and electron microscope after induced 5 min to 6 h. Main pathological changes: hemorrhage and necrosis appear in pancreas, fibrin thrombus, white thrombus and mixed thrombus in small vessels. With the development of the disease pathological changes were aggravated. The result suggests: AHNP is associated with self-digestion and microcirculation disturbance.
出处
《首都医科大学学报》
CAS
2004年第3期307-310,共4页
Journal of Capital Medical University
关键词
AHNP
急性胰腺炎
病因
病理学
诱导
病变
微血栓
染色
白色
普通
acute hemorrhagic and necrotic pancreatitis (AHNP)
pathologic change
self-digestion
microcirculation disturbance
