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正交设计优化尼美舒利NLC处方组成与制备工艺 被引量:1

Optimization of Formulation and Preparation Parameters for Nimesulide Loaded NLC by Orthogonal Design
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摘要 运用高压均质法制备了加载尼美舒利的纳米结构脂质载体(Nanostructured Lipid Nanoparticles,NLC),采用单因素设计考察了固液态油脂比、脂质用量、乳化剂用量、药脂比、均质压力和均质次数对纳米粒质量的影响。采用正交设计优化了制备条件。确定的最适宜制备方案为油酸与单硬脂酸甘油酯(glycerin monostearate,GMS)投料比为3∶10,药脂比为1∶40,TPGS用量为1.4 g,均质压力为90 MPa。依据最适宜处方制备的纳米粒粒径为132.6±1.4 nm,包封率为82.35±1.23%。扫描电镜显示所制备纳米粒呈类球形,体外释放实验表明其释放行为符合Higuchi模型。 High pressure homogenization method was used to prepare Nimesulide loaded nanostructured lipid nanoparticles(NLC).Single factor design was chosen to study the influence of solid-liquid lipid ratio,amount of lipid,amount of emulsifier,drug-lipid ratio,homogenization pressure and homogenization cycles on quality of the prepared nanoparticles.Orthogonal design was used to optimize the preparation parameters.The optimal preparation method was 3∶ 10 of oleic acid-glycerin monostearate(GMS) ratio,1∶ 40 of drug-lipid ratio,1.4 g of TPGS,90 MPa of homogenization pressure.Particle size and entrapment efficiency of NLC prepared by optimal conditions were 132.6 ± 1.4 nm and 82.35 ± 1.23%,respectively.The scanning electron microscope showed that the nanoparticles were of spherical shape.The in vitro release study showed that release behavior accorded with Higuchi model.
出处 《化学工业与工程》 CAS 2014年第4期46-51,共6页 Chemical Industry and Engineering
关键词 正交设计 NLC 高压均质法 尼美舒利 优化 orthogonal design nanostructured lipid nanoparticles(NLC) homogenization method Nimesulide optimization
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  • 1Muller R H, Shegokar R, Keck C M. 20 years of lipid nanoparticles ( SLN & NLC ) : Present state of develop- ment & industrial applications [ J ]. Current Drug Dis- covery Technologies, 2011, 8:207-227. 被引量:1
  • 2Teeranachaideekul V, Muller R H, Junyaprasert V B. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers ( NLC ) : Effects of formulation parameters on physicochemical stability[ J ]. International Journal of Pharmaceutics, 2007, 340 : 198 - 206. 被引量:1
  • 3Han F, Yin R, Che X, et al. Nanostructured lipid car- riers (NLC) based topical gel of flurbiprofen: Design, characterization and in vivo evaluation[ J]. International Journal of Pharmaceutics, 2012,439 ( 1/2 ) : 349 - 357. 被引量:1
  • 4韩飞,刘洪卓,李三鸣.固体脂质纳米粒和纳米结构脂质载体在经皮给药系统中的研究进展[J].沈阳药科大学学报,2008,25(10):839-844. 被引量:20
  • 5李智..超声法制备紫杉醇固体脂质纳米粒的研究[D].沈阳药科大学,2008:
  • 6Jores K, Mehnert W, Drechsler M, et al. Investigations on the structure of solid lipid nanoparticles ( SLN ) and oil-loaded solid lipid nanoparticles by photo correlation spectroscopy, field-flow fractionation and transmission e- lectron microscopy [ J ]. Journal of Controlled Release, 2004, 95:217-227. 被引量:1
  • 7Hu F, Jiang S, Du Y, et al. Preparation and character- ization of stearic acid nanostructured lipid carriers by sol- vent diffusion method in an aqueous system[ J]. Colloids and Surfaces B : Biointerfaces, 2005, 45 : 167 - 173. 被引量:1
  • 8Teeranachaideekul V, Souto E B, Junyaprasert V B, et al. Cetyl palmitate-based NLC for topical delivery of Co- enzyme Q10-development, physicochemical characteriza- tion and in vitro release studies [ J ]. European Journal of Pharmaceutics and Biopharmaceutics, 2007, 67 ( 1 ) : 141 - 148. 被引量:1
  • 9Mehnert W, Mader K. Solid lipid nanoparticles: Pro- duction, characterization and applications [ J ]. Ad- vanced Drug Delivery Reviews, 2012, 64:83 -101. 被引量:1
  • 10Siekmann B, Westesen K. Melt-Homogenized solid lipid nanoparticles stabilized by the nonionic surfactant tylox-apol. I. Preparation and particle size determination[J]. Pharmaceutical and Pharmacological Letters, 1994, 3: 194 - 197. 被引量:1

二级参考文献25

  • 1刘卫,朱姚亮,陈华兵,杨祥良.Characteristics and Transdermal Drug Delivery of Triamcinolone-Acetonide-Acetate-Loaded Solid Lipid Nanoparticles Carbomer Gel[J].Journal of Chinese Pharmaceutical Sciences,2005,14(1):18-24. 被引量:3
  • 2陆杨燕,周华锋,夏强,马全红,顾宁.维甲酸固体脂质纳米粒的制备及兔体外透皮研究[J].中国医药工业杂志,2006,37(1):17-19. 被引量:3
  • 3SCHWARZ C, MEHNERT W. Solid lipid nanoparticles (SLN) for controlled drug delivery Ⅱ:Drug incorparation and physicochemical characterization [ J ]. J Microencapsul, 1999, 16(2) :205 - 213. 被引量:1
  • 4MULLER R H, RADTKE M, WISSING S A. Nanostructured lipid matrices for improved microencapsulation of drugs [ J ]. Int J Pharm, 2002, 242 ( 1/2 ) : 121 - 128. 被引量:1
  • 5MULLER R H, MADER K, GOHLA S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art [ J ]. Eur J Pharm Biopharm, 2000, 50( 1 ) : 161 - 177. 被引量:1
  • 6MULLER R H, RADTKE M, WISSING S A. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological prepara- tions [ J ]. Adv Drug Deliv Rev, 2002, 54 ( Suppl 1 ) : S131 - 155. 被引量:1
  • 7JENNING V, THUNEMANN A F, GOHLA S H. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids [J]. Int J Pharm, 2000, 199:167 - 177. 被引量:1
  • 8SIVARAMAKRISHNAN R, NAKAMURA C, MEHNERT W, et al. Glucocorticoid entrapment into lipid earriers-characterisation by parelectrie spectroscopy and influence on dermal uptake [J].J Control Rdease, 2004, 97(3) :493 - 502. 被引量:1
  • 9LOMBARDI B S, REGEHLY M, SIVARAMAKRISHNAN R, et al. Lipid nanoparticles for skin penetration enhancement-correlation to drug localization with-in the particle matrix as determined by fluorescence and parelectric spectroscopy [ J ]. J Control Release, 2005, 110(1) : 151 - 163. 被引量:1
  • 10MEI Zhi-nan, CHEN Hua-bing, WENG Ting, et al. Solid lipid nanoparticle and microemulsion for topical delivery of triptolide [ J ]. Eur J Pharrn Biopharm, 2003.56:189 - 196. 被引量:1

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