摘要
目的探讨皮服辐射防护膏(RPA)软膏基质组成及制备工艺。方法以RPA软膏在高温加热时发生分层的时间为考察指标,采用正交设计法筛选RPA软膏的基质组成及乳化温度。结果初步筛选RPA软膏最佳基质组成为硬脂酸12.5 g,液体石蜡12.5 g,三乙醇胺0.5 g,甘油8.0 g,吐温80 2.0 g,最佳乳化温度75℃。结论该研究确定的最佳基质组成与最佳乳化温度可以制备质量稳定的RPA软膏。
Objective To probe into the composition of the ground substance and preparation technology of the radioprotectant(RPA)ointment. Methods The delamination time of the RPA ointment during heating was adopted as the trial index for screening of the composition of the ground substance and the emulsification temperature of the drug with an orthogonal design. Results The optimal composition of the ground substance of the RPA ointment was shown to be as follows: stearic acid 12.5 g,liquid paraffin 12.5 g,triethanolamine 0.5 g,glycerine 8.0 g,Tween-80 2.0 g,and the optimal emulsification temperature was 75 ℃. Conclusion RPA ointment of stable quality could be prepared by adopting the optimal composition of the ground substance and optimal emulsification temperature confirmed in the present study.
出处
《医药导报》
CAS
2006年第10期1047-1048,共2页
Herald of Medicine
基金
佛山市科技发展专项资金项目(基金编号:03080161)
佛山市医学科学技术研究项目(基金编号:2006289)
关键词
辐射防护剂
软膏
制备工艺
Radioprotectant
Ointment
Preparation technology
