摘要
目的调查医院感染患者的抗菌药物使用情况，为临床合理使用抗菌药物提供参考依据。方法回顾性调查123例医院感染患者的临床资料，统计分析抗菌药物的使用情况。结果123例住院感染患者中送检采样标本65例，送检率为52．85％；感染部位以上呼吸道、下呼吸道和泌尿道为主，分别占35．77％、30．90％、17．07％；共培养出病原菌65株，前3位病原菌依次为大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌，分别占35．39％、27．69％、13．85％；使用抗菌药物时间最长的12d，平均为4～6d，平均使用抗菌药物≥2种，其中用药频次最高的第二代头孢菌素占39．83％，其次为第一代和第三代头孢菌素，分别占29．27％和17．07％，应用较少的为氨基糖苷类和喹诺酮类，仅占4．07％，抗菌药物单联使用率占50．41％，联合应用比率占49．59％。结论医院感染患者使用抗菌药物品种选择档次高、联合用药多、用药指征不明确、经验性用药问题多、使用时间长，需加大专项培训和整治力度，强化规范性用药。
OBJECTIVE To investigate the use of the antibacterial agents for nosocomial infection patients, so as to provide reference for the rational use of antibacterial agents. METHODS The clinical data of 123 nosocomiai infec- tion patients were retrospectively studied, and a statistical analysis was made to those antibacterial agents. RESULTS Among 123 cases, 65 cases were selected for investigation and ana}ysis with a rate of 52.85% ; it was found that the infection sites were mostly upper respiratory tract （35.77 %）, lower respiratory tract （30.90 %） and urinary tract （17.07%）. Totally, 65 strains of pathogens were cultured, and the dominant pathogens were Escherichia coli （35.39%）, Klebsiella pneumonia （30.90%） and Staphylococcus aureus （13.85%）. The longest time of taking anti-bacterial drugs lasted 12 days, and it lasted 4 to 6 days on average; two or more than two anti- bacterial agents were used averagely, of which the second generation cephalosporin was used with the most times and accounted for 39.83%, followed by the first generation cephalosporins （29. 27%） and the third generation eephalosporins （17.07%）; aminoglycosides and quinolones were barely used and accounted for 4.07% only; the rate of single joint use of antibacterial agent was 50.41%, and that of combined use was 49.59%. CONCLUSION It is necessary to strengthen efforts on specified training and improvement for standardization of medication, so as to avoid such prohlems as high grade, high dose, ambiguous medical indication, experimental medication and long- time medication.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第10期2417-2418,2421,共3页
Chinese Journal of Nosocomiology
基金
甘肃省科技计划基金资助项目(201103056)
关键词
医院感染
抗菌药物
应用
调查分析
Nosocomial infection
Antibacterial agents
Application
Investigation and analysis
