摘要
目的观察布拉氏酵母菌辅助治疗成人感染性腹泻的效果。方法采用随机数字表法将2014年1月至2018年10月运城市中心医院收治的200例成人感染性腹泻患者随机分为实验组和对照组,每组100例。实验组采用布达拉氏酵母菌联合左氧氟沙星治疗,对照组采用左氧氟沙星治疗。比较两组患者临床总有效率,以及治疗前、治疗后3d症状改善情况(每日排便次数、腹泻持续时间),治疗前、治疗后5d免疫功能相关指标(T淋巴细胞CD4^+、CD8^+、CD4^+/CD8^+)以及血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、内毒素]水平的变化情况。结果实验组治疗总有效率(92.00%)高于对照组(66.00%),差异有统计学意义(P<0.05)。治疗后3d,对照组、实验组患者每日排便次数[(1.53±0.16)、(1.45±0.13)d]均较治疗前减少[(6.73±1.21)、(6.75±0.92)d],P均<0.05,实验组变化更为显著(P<0.05);且实验组腹泻持续时间[(1.64±0.32)d]短于对照组[(2.17±0.28)d],P<0.05。治疗后5d,两组患者CD4^+、CD4^+/CD8^+水平均较治疗前升高(P均<0.05),CD8^+水平均治疗前降低(P均<0.05),且实验组上述指标变化更为显著(P均<0.05)。治疗后5d,两组患者TNF-α、IL-1β、CRP、内毒素水平均较治疗前降低(P均<0.05),且实验组低于对照组(P<0.05)。结论布拉氏酵母菌辅助治疗成人感染性腹泻可提高疗效,改善患者免疫功能,缓解炎症反应。
Objective To observe the effects of Saccharomyces boulardii adjuvant therapy in the treatment of infectious diarrhea in adults. Methods A total of 200 adult patients with infectious diarrhea admitted to the Yuncheng Central Hospital from January 2014 to October 2018 were divided into experimental group and control group by the random number table method, with 100 cases in each group. Patients in experimental group were treatment with Saccharomyces boulardii combined with levofloxacin, while patients in control group were treatment with levofloxacin. The total effective rate, improvement of symptoms (daily defecation frequency, diarrhea duration) before treatment and 3 days after treatment, and related indicators of immune function (T lymphocytes CD4^+, CD8^+, CD4^+/CD8^+) andserum inflammatory factors, including tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), endotoxin, before treatment and 5 days after treatment were compared between the two groups. Results The total effective rate of treatment in experimental group (92.00%) was significantly higher than that in control group (66.00%), and the difference was statistically significant (P<0.05). The daily defecation frequency of control group and experimental group were (1.53±0.16)d and (1.45±0.13)d, respectively 3 days after treatment, which were lower than the (6.73±1.21)d,(6.75±0.92)d before treatment (all P<0.05), and the change was more significant in experimental group (P<0.05). The diarrhea duration in experimental group was (1.64±0.32)d, significantly shorter than the (2.17±0.28)d in control group (P<0.05). The levels of CD4^+ and CD4^+/CD8^+ in the two groups 5 days after treatment were increased compared with those before treatment (all P<0.05);and the CD8^+ levels in the two groups were reduced compared with that before treatment (all P<0.05);and the changes of above indexes were more significant in experimental group (all P<0.05). The levels of TNF-α, IL-1β, CRP and endotoxin in the two groups were significantl
作者
马亚丽
马敏
Ma Yali;Ma Min(Department of Infectious Diseases, Yuncheng Central Hospital, Yuncheng 044000, China;Department of Emergency, Yuncheng Central Hospital, Yuncheng 044000, China)
出处
《中国实用医刊》
2019年第11期106-109,共4页
Chinese Journal of Practical Medicine
关键词
布拉氏酵母菌
左氧氟沙星
成人
感染性腹泻
临床疗效
Saccharomyces boulardii
Levofloxacin
Adults
Infectious diarrhea
Clinical efficacy
