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血浆置换治疗抗结核药物导致的亚急性肝衰竭患者23例 被引量:6

Plasma exchanges in treatment of patients with antitubercular agent-induced subacute hepatic failure
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摘要 目的探讨在常规内科治疗的基础上加用血浆置换治疗抗结核药引起的肝衰竭患者的疗效。方法将45例抗结核药物引起的亚急性肝衰竭患者分为两组,全部患者停用抗结核药。给予22例患者积极护肝,输血浆、白蛋白,防治并发症;23例患者在上述治疗的基础上加用血浆置换治疗,观察两组患者肝功能指标的变化、病死率和平均住院日的差别。结果在22例常规治疗组,平均住院(86.7±10.3)天,死亡4例(18.2%),在23例血浆置换治疗组,平均住院(65.9±9.7,P<0.05)天,死亡1例(4.3%,P<0.05);在常规治疗组,22例患者在治疗前血清总胆红素、白蛋白、INR和ALT水平分别为(358.1±135.7)μmol/L、(32.9±5.2)g/L、(1.7±0.7)和(1356.1±456.2)U/L,在治疗后,18例生存患者分别为(35.3±15.7)μmol/L、(36.8±3.2)g/L、(1.1±0.2)和(87.8±12.2)U/L。在血浆置换治疗组,23例患者在治疗前分别为(348.1±145.8)μmol/L、(32.3±4.9)g/L、(1.8±0.8)和(1416.3±389.9)U/L,在治疗后,22例生存患者分别为(22.3±9.7)μmol/L、(36.2±3.3)g/L、(1.1±0.5)和(52.8±17.5)U/L。结论在抗结核药引起的肝衰竭患者,在停用抗结核药后给予常规内科治疗,再联合血浆置换治疗可提高疗效。
作者 韦贞伟
出处 《实用肝脏病杂志》 CAS 2014年第3期315-316,共2页 Journal of Practical Hepatology
关键词 肝衰竭 抗结核药物 血浆置换 疗效 Subacute hepatic failure Plasma exchanges Antitubercular agents
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参考文献10

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