摘要
目的观察血浆置换治疗对药物性肝衰竭的疗效。方法治疗组28例患者在内科综合治疗的基础上联合血浆置换治疗。对照组30例仅给予内科综合治疗。结果治疗组好转率为82.1%(23/28)),平均住院为28d,对照组好转率为53.3%(16/30),平均住院日为41d。治疗组患者并发症如肝性脑病,中毒性鼓肠明显改善;治疗组治疗前后血清总胆红素别为(586±188)μmol/L和(212±96)μmol/L,血氨分别为(57±12)μmol/L和(39±19)μmol/L,凝血酶原活动度分别为(32±4)%和(72±18)%,对照组治疗前后血总胆红素,血氨,凝血酶原活动度的改善不如治疗组明显,两组相比,差异有统计学意义(P<0.05)。结论在内科治疗的基础上联合血浆置换治疗可明显提高药物性肝衰竭的疗效。
Objective To assess the effect of the plasma exchange （PE） in drug induced liver failure. Methods 28 patients with drug-induced liver failure were treated with plasma exchange besides medical treatment. 30 patients as control group were given medical treatment only. Resuits The cure rate was 82.3%（23/28） in the therapeutic group and 53.3%（16/30） in the control group respectively.The hospitalization time were 28 days in the therapeutic group and 41 days in the control group.The clinical symptoms （such as hepatic encephalopathy and toxic enteroparalysis） and the laboratory data（serum total bilirubin, blood ammonia and prothrombin activity） of the therapeutic group was obviously improved compared with those of the control group （P〈0.05）. Conclusion PE can improve the efficacy of therapy for drug induced liver failure.
出处
《药品评价》
CAS
2007年第6期405-407,共3页
Drug Evaluation
