摘要
动脉粥样硬化(atherosclerosis,AS)是多种细胞、炎症介质产生参与的慢性炎症性疾病。Toll样受体家族(Toll like receptors,TLRs)中的TLR-4是机体重要的诱导分泌多种炎症因子的模式识别受体。有证据表明,TLR-4不仅产生多种炎症因子诱发血管炎症反应,而且促进AS斑块形成和发展,从而造成斑块不稳定、甚至破裂,对AS的发生、发展具有重要作用。因此,了解TLR-4对AS的影响将有助于发现新的治疗靶点和对策。本文主要对TLR-4在AS发病机制和发展中的作用进行综述。
Atherosclerosis （AS） is a multi -factorial chronic inflammatory disease, which is caused by variety of cells. Inflam- mation mediators. TLR - 4, the member of the family of toll like receptors （TLRs）, is an important receptors of pattern recognition receptors, could induce the secretion of many inflammatory cytokines. The available evidence suggests that TLR - 4 may play a pivotal role in initiation and progression of atherosclerosis, leading to beneficial to the discovery of new therapeutic target and strategies. In this review, we discuss the effect of TLK4 in the pathogenesis and development of AS.
出处
《中国优生与遗传杂志》
2014年第4期4-5,10,共3页
Chinese Journal of Birth Health & Heredity
