摘要
目的探讨急性时相反应蛋白检测在判断慢性阻塞性肺疾病急性加重(AECOPD)患者感染类型,以及在评判疾病严重程度中的价值。方法选择125例COPD患者为研究对象。检测血清中的α1-酸性糖蛋白(AAG),触珠蛋白(HPT),铜蓝蛋白(CER),转铁蛋白(TRF),C-反应蛋白(CRP),前白蛋白(PAB)。按细菌培养结果分为痰培养阳性组和培养阴性组。按照血气分析结果分为单纯性AECOPD组及AECOPDP伴呼吸衰竭组。结果痰培养阳性组和培养阴性组之间CRP差别有统计学意义(P<0.01),其余指标差别无统计学意义(P>0.05)。区分细菌性AECOPD和非细菌性AECOPD的理想分界点为39.06 mg/L(灵敏度,85.05%,特异度89.61%,AUC,0.852)单纯性AECOPD组AAG,CER与AECOPDP伴呼吸衰竭组差异有统计学意义(P<0.05,P<0.01)其他指标差异均无统计学意义。检验效能CER好于AAG且联合检测意义不大。结论 CRP有助于AECOPD感染类型的早期诊断,CER可作为疾病严重程度的判断指标。
Objective To study the value of acute phase protein in judging the infection type and the disease severity of patients with chronic obstructive pulmonary diseases acute exacerbation （AECOPD）. Methods One hundred and twenty -five cases of COPD patients were chosen as the research objects to detect the serum alpha 1 - acid glycoprotein （ AAG）, haptoglobin （HPT）, eeruloplasmin （CER）, transferrin （TRF）, C- reactive protein （CRP） and prealbumin （PAB）. According to the bacterial culture results, the patients were divided into sputum culture positive group and negative group. According to blood gas analysis results, the patients were divided into simple AECOPD group and AECOPDP associated with respiratory failure group. Results The CRP value in sputum culture positive group was significant higher compared to negative group （ P 〈 0.01 ）, while the difference of the rest index had no statistical significance （P 〉 0.05 ）. To distinguish bacterial AECOPD and nonbacterial AECOPD, the ideal cut - off point was 39.06 mg/L （ sensitivity ： 85.05%, specificity ： 89.61%, AUC ： 0. 852）. AAG and CER in AECOPD respiratory failure groups had significant difference （ P 〈 0.05, P 〈 0.01 ） compared with simple AECOPD group, and other indexes had no significant differences. Test effectiveness of CER was better than AAG, making little sense of joint detection. Conclusion CRP is helpful to early diagnosis of infection types of AECOPD, so it can he used as an indicator to judge the severity of disease.
出处
《中国卫生检验杂志》
北大核心
2014年第1期97-99,共3页
Chinese Journal of Health Laboratory Technology
