摘要
目的：建立培菲康胶囊中铅、砷、镉、汞4种有害元素的测定方法。方法：采用电感耦合等离子体质谱法，样品经微波消解前处理后测定，选择内标法定量以消除基体效应和干扰。结果：在一定的浓度范围内，各元素和内标元素的质量数比值均与浓度呈良好的线性关系，相关系数均大于0.999，加样回收率为73.5%～103.2%，检测限均满足测定的要求。结论：该方法专属性好，灵敏度高，准确快捷，可为同类药品、保健品中有害元素的限量检查提供参考。
Objective： To establish a method for the determination of four harmful elements of lead（Pb）,arsenic（As）,mercury（Hg）and cadmium（Cd）in Bifico capsules. Methods： Harmful elements were determined by inductively coupled plasma-mass spectrometry,using microwave digestion for sample pretreatment.The internal standard solution was used to eliminate the matrix effect and interference. Results： The mass ratio of each measured element,the corresponding internal standard element and the concentration showed a good linear relationship in a certain concentration range,and the correlation coefficients were all greater than 0.999.The recoveries were from 73.5% to 103.2%,and the detection limits all met the requirements of determination. Conclusion： The method is specific,sensitive,accurate and rapid,and can be used for the limit determination of harmful elements in similar drugs and health products.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2014年第1期136-139,共4页
Chinese Journal of Pharmaceutical Analysis
