摘要
以α-溴代苯乙酮和硫脲为原料,正丙醇为溶剂,制得2-氨基-4-苯基噻唑,通过元素分析、红外光谱、1H NMR和MS确定化合物的结构。运用正交实验筛选出最佳工艺条件:反应时间为6 h,温度为97℃(回流),α-溴代苯乙酮和硫脲摩尔比为1:1.10,2-氨基-4-苯基噻唑的产率可达97%。该方法具有安全,易控制,操作简便,后处理简单等优点,适合工业化生产。
In the paper, 2-amino-4-phenylthiazole was synthesized by reaction of α-bromoacetophenone and thiourea with 1-propanol as solvent, its structure has been determined by elemental analysis, IR, 1H NMR and MS. The optimum condition which was selected by orthogonal experiments is at 97 ℃（reflux） for 6 h, the ratio of α-bromoacetophenone and thiourea was 1：1.10（mol）, and the yield reached 97 %. This method has the characteristics of safety, easy control and simple operation. It has valuable for industrial applied.
出处
《广东化工》
CAS
2014年第1期28-28,41,共2页
Guangdong Chemical Industry
基金
广西民族师范学院科研基金资助项目(2012XYYB001)
广西高校优秀人才资助计划(RC2007043)
关键词
2-氨基-4-苯基噻唑
合成
硫脲
正交实验
2-amino-4-phenylthiazole； synthesis
thiourea； orthogonal experiments
