摘要
噻唑类化合物具有良好的杀菌、抗病毒、抗肿瘤等活性。以噻唑及其衍生物作为母体与其他具有良好活性的基团构建成具有更高活性的新化合物逐渐成为研究的热点。腙类化合物在抑菌、消炎、抗肿瘤等方面也表现出较强的生物活性。因此,将噻唑基团和腙基团融合在同一化学结构中有望得到具有更高生物活性的化合物。以α-溴代苯乙酮、氨基硫脲和丙酮为原料,回流反应1 h,通过"一锅法"合成了7个目标化合物,同时对所得的7个目标化合物结构进行表征,结果表明,表征数据与分子结构相匹配。与以往的噻唑腙类化合物的合成相比,方法具有反应时间短、选择性高、副产物少及后处理简单等优点。
Thiazole compounds have good bactericidal,antiviral,anti-tumor and other activities.Combination of thiazole or its derivatives with other groups,which obtained good activity,to build novel compounds with higher activity has gradually become a research hotspot.Hydrazone compounds also showed strong biological activity in bacteriostasis,anti-inflammatory,anti-tumor and other aspects.Therefore,it was expected to obtain compounds with higher biological activity by constructing thiazole group and hydrazone group in the same chemical structure.Seven target compounds with thiazole ring and hydrazine as active groups were synthesized by one-pot method by usingα-bromophenylacetone,thiosemicarbazide and acetone as raw materials under reflux condition for 1 h.The structures of seven target compounds were confirmed by 1HNMR,13CNMR,ESI-MS and FT-IR.The characterization data of the compounds matched with their molecular structures.Compared with the previous methods,the method had the advantages of short reaction time,high selectivity,few by-products and simple post-treatment.
作者
石云飞
叶圣丰
陈淑兰
司红燕
陈尚钘
王宗德
廖圣良
SHI Yun-fei;YE Sheng-feng;CHEN Shu-lan;SI Hong-yan;CHEN Shang-xing;WANG Zong-de;LIAO Sheng-liang(East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration,Jiangxi Agricultural University,Nanchang 330045,China;Camphor Engineering Research Center of National Forestry and Grassland Administration/Jiangxi Province,Jiangxi Agricultural University,Nanchang 330045,China;Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization,College of Forestry,Jiangxi Agricultural University,Nanchang 330045,China)
出处
《化学试剂》
CAS
北大核心
2020年第2期216-220,共5页
Chemical Reagents
基金
国家自然科学基金青年基金项目(31800493)
江西省林业科技创新项目(201807)
江西省教育厅科学技术研究项目(GJJ160364,GJJ170255)。
关键词
氨基硫脲
合成
噻唑腙
一锅法
席夫碱
thiosemicarbazide
synthesis
thiazole hydrazon
one-pot method
Schiff base
