摘要
目的 探讨脂蛋白相关磷脂酶A2（Lp-PLA2）对急性冠脉综合征（ACS）的预测价值.方法 选择ACS患者48例为研究对象,ACS患者中稳定型心绞痛患者（SAP组）27例不稳定型心绞痛组（UAP组）22例,急性心肌梗死组（AMI组）26例,健康对照组选取同期该院体检未发现心血管疾病者21例.采用酶联免疫吸附法（ELISA）,检测血浆Lp-PLA2水平.采用西门子7600-20全自动生化分析仪测定血清乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、肌红蛋白（MYO）、三酰甘油（TG）、胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）.结果 不同组别中的Lp-PLA2水平明显不同（F=10.801,P=0.000）.多重比较显示,SAP组、UPA组和AMI组的Lp-PLA2水平明显高于健康对照组（P〈0.05）,AMI组的Lp-PLA2水平明显高于SAP组或UAP组（P〈0.05）.AMI组TG、HDL、LDH、CK、CK-MB和MYO水平明显高于健康对照组,差异有统计学意义（P〈0.05）;而LDL和TC水平差异无统计学意义（P〉0.05）,Lp-PLA2水平与LDL、LDH、CK-MB和MYO正相关,与HDL负相关.受试者工作特征（ROC）曲线分析,Lp-PLA2水平在诊断ACS过程中曲线下面积为0.834（P=0.000）,95%CI为0.740～0.928.结论 高水平血浆Lp-PLA2对ACS患者发生心血管事件有一定的预测价值.
Objective To observe the levels of plasma lipoprotein-associated phospholipase A2（Lp-PLA2） in patients with acute coronary syndrome（ACS）. Methods There were four groups：stable angina pectoris group（SAP group, 27 cases）, variant angina pectoris（UAP group, 22 cases） ,acute myocardial infarction（AMI group, 26 cases） and healthy control group（21 cases）. Plasma Lp- PLA2 levels were detected by enzyme linked immunosorbent assay（ELISA）, and serum biochemical indexes were determined with automated biochemical analyzer. Results The level of plasma Lp-PLA2 was significantly different in different groups（P〈0.05）. Compared with control group, the level of plasma Lp-PLA2 was higher in SAP group or UPA group or AMI group（P〈0.05）. The plasma level of Lp-PLA2 was higher in AMI group than that of SAP group or UPA group（P〈0.05）. TG, HDL,LDH ,CK,CK-MB and MYO in AMI group were significantly higher than those in control group（P〈0.05）, but LDL and TC were not significantly different（P〉0.05）. The plasma level of Lp-PLA2 was correlated evidently with LDL,LDH ,CK-MB,MYO and HDL. The area un- der curve（AUC） of Lp-PLA2 was 0. 834,95%CI was 0. 740-0. 928. Conclusion The increased plasma level of Lp-PLA2 may be a risk factor in ACS.
出处
《国际检验医学杂志》
CAS
2013年第24期3316-3317,3319,共3页
International Journal of Laboratory Medicine
基金
湖南省卫生厅基金项目(B2012-086)
