摘要
残粒脂蛋白被认为是致动脉粥样硬化的脂蛋白。脂肪细胞分泌的各种促炎脂肪因子在动脉粥样硬化发生、发展的慢性炎症反应中起重要作用。肥胖是冠心病和动脉粥样硬化的一个独立危险因素。残粒脂蛋白通过刺激促炎脂肪因子的释放、诱导前体脂肪细胞向成熟脂肪细胞的成脂分化,从而促进动脉粥样硬化的发生发展。此外,脂肪细胞对残粒脂蛋白代谢的调节也可能影响残粒脂蛋白在体内致动脉粥样硬化作用的强度。
Remnant-like lipoprotein particles have been implicated as potentially atherogenic lipoproteins.A variety of proinflammatory adipocytokines secreted by adipocytes play an important role in the development of chronic inflammation of atherosclerosis.Obesity is an independent risk factor of coronary heart disease and atherosclerosis.Remnant-like lipoprotein particles accelerate atherosclerosis events through stimulating the release of proinflammatory adipocytokines and inducing adipogenic differentiation from preadipocytes to mature adipocytes.In addition,the effects of adipocytes on remnant-like lipoprotein particles metabolism may impact the atherogenic intensity of remnant-like lipoprotein particles in vivo.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第1期72-75,共4页
Chinese Journal of Arteriosclerosis
基金
中华医学会动脉粥样硬化研究专项资金(09010570212)资助
湖南省杰出青年基金(10JJ1008)资助
中南大学湘雅二医院代谢综合征研究中心资助课题(DY-2008-01-01)
关键词
残粒脂蛋白
脂肪细胞
炎症
动脉粥样硬化
Remnant-Like Lipoprotein Particles
Adipocytes
Inflammation
Atherosclerosis
