摘要
目的探讨同型半胱氨酸(HCY)等危险因子在动脉粥样硬化疾病中的表达差异及与该疾病的相关性。方法对120例脑梗死患者、103例冠心病患者、43例动脉闭塞症患者以及50例健康对照人群同时测定血清低密度脂蛋白(LDL)、脂蛋白a[Lp(a)]、尿酸(UA)、HCY、超敏C反应蛋白(HS-CRP),并作对比分析及多元回归分析。结果脑梗死、冠心病以及动脉闭塞组的血清HCY、LDL、Lp(a)、UA、HS-CRP表达水平与健康对照组差异有统计学意义(Hc=76.789、13.982、21.788、28.550,χ2=16.041,P<0.05)。多元回归分析显示,不同危险因子与不同动脉粥样硬化疾病的相关性不同。结论 HCY、LDL、Lp(a)、UA、HS-CRP水平增高与动脉粥样硬化疾病密切相关,并且各危险因子与各疾病相关程度不同,及早检测各危险因子,对动脉粥样硬化疾病的预防、治疗有着非常积极的意义。
Objective To investigate the relationship between atherosclerosis diseases and the risk factors,such as homocysteine（HCY）,and to analyze the differences of the risk factors in different atherosclerosis diseases.Methods The serum levels of low-density lipoprotein（LDL）,lipoprotein（a）[Lp（a）],uric acid（UA）,HCY and high sensitive-C reaction protein（HS-CRP） were parallel detected in 120 cases of patients with acute cerebral infarction（ACI group）,103 cases with coronary heart disease（CHD group）,43 cases with peripheral artery disease（PAD group） and 50 healthy controls（control group）.The contrastive analysis and multivariate analysis were conducted.Results ACI,CHD and PAD group all showed significant differences from the control group,including the serum levels of LDL,Lp（a）,UA,HCY and HS-CRP（Hc=76.789,13.982,21.788,28.550,χ2=16.041,P0.05）.Multivariate analysis indicated that each risk factor had a different degree of correlation with different atherosclerosis diseases.Conclusion The serum levels of LDL,Lp（a）,UA,HCY and HS-CRP could be closely related with atherosclerosis diseases.Each risk factor might have a different degree of correlation with different atherosclerosis diseases.Early detection of LDL,Lp（a）,UA,HCY and HS-CRP could have positive significance for preventing and curing atherosclerosis diseases.
出处
《国际检验医学杂志》
CAS
2012年第1期40-41,44,共3页
International Journal of Laboratory Medicine
