摘要
目的探讨川芎嗪对急性脑梗死患者血清超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、基质金属蛋白酶9(MMP-9)水平的影响。方法 68例急性脑梗死患者随机分为观察组和对照组,每组34例。对照组采用常规基础治疗,观察组在基础治疗的基础上加用川芎嗪注射液。观察2组治疗前后血清中hs-CRP、IL-6、MMP-9水平,评价治疗后的临床疗效。结果2组临床疗效无显著差异。观察组和对照组治疗后血清hs-CRP、IL-6、MMP-9水平均较治疗前明显降低。观察组治疗后血清hs-CRP、IL-6、MMP-9水平均明显低于对照组治疗后。结论川芎嗪可降低急性颈内动脉系统脑梗死患者血清IL-6、MMP-9、hs-CRP水平,并可改善神经功能。
Objective To explore the effects of Chuanxiongqin injection on serum high-sen- sitivity C-reactive protein （hs-CRP）, interleukin-6 （IL-6） and matrix metalloproteinases-9 （MMP- 9） in treating acute cerebral infarction （ACI）. Methods Sixty-eight patients with ACI were ran- domly divided into control group and observation group, 34 for each. The former received routine treatment while the latter was added with intravenous injection of Chuanxiongqin injection. The levels of serum hs-CRP, IL-6 and MMP-9 before and after treatment were observed in two groups, and the clinical effects was evaluated after treatment. Results There was no significant difference in clinical effect in both groups. The levels of serum hs-CRP, IL-6 and MMP-9 in both groups de- creased evidently after treatment, whereas those in observation group were more remarkable. Con- elusion Chuanxiongqin injection can significantly reduce the levels of serum hs-CRP, IL-6 and MMP-9 in patients with ACI in acute internal carotid system, and improve the neurological func- tion.
出处
《实用临床医药杂志》
CAS
2013年第17期78-80,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321155)
关键词
川芎嗪
脑梗死
白细胞介素-6
基质金属蛋白酶-9
超敏C反应蛋白
Chuanxiongqin
acute cerebral infarction
interleukin-6
matrix metallopro-teinases-9
high-sensitivity C-reactive protein
