摘要
目的 分析超敏C反应蛋白(hs CRP)联合ABCD2评分在短暂性脑缺血发作(TIA)患者中的临床应用价值.方法 对2010年5月至2011年2月在滨州医学院附属医院住院的106例颈内动脉系统TIA患者,行ABCD2评分[低危组(0～3分)、中危组(4～5分)、高危组(6～7分)],并测定hs CRP数值,同时行hs CRP+ABCD2评分[低危组(0～3分)、中危组(4～5分)、高危组(6～8分)]以患者第7天发生脑梗死为终点事件,分析TIA患者ABCD2评分与hs CRP关系,应用ROC曲线比较ABCD2、hs CRP+ABCD2评分在评价TIA临床转归中的差异.结果 106例TIA患者7d内有24例进展为脑梗死,占总病例数的22.6%.低危组TIA患者33例,进展为脑梗死者1例,脑梗死发生率为3.0%;中危组TIA患者55例,进展为脑梗死者12例,脑梗死发生率为21.8%;高危组TIA患者18例,进展为脑梗死者11例,脑梗死发生率为61.1%.随着TIA患者ABCD2评分数值的升高,患者的hs CRP数值呈现上升趋势,高危组患者hs CRP水平上升幅度最高,其次是中危组,低危组hs CRP上升幅度最小;ABCD2+hs CRP评分在评价TIA患者临床转归结局中优于ABCD2评分.结论 ABCD2评分联合hs CRP可提高ABCD2评分的临床应用价值,筛选高危TIA患者,指导临床治疗.
Objective To explore the clinical application of high sensitive C reactive protein(hs-CRP)combined with ABCD2 score in patients with transient ischemic attack(TIA).Methods One hundred and six patients with TIA of affiliated hospital of Binzhou medical college from may 2010 to Feberary2011 were involved in this study.The ABCD2 score[ABCD2 score of low risk(0-3),a score of moderate risk(4-5),a score of high risk(6-7)],the hs-CRP,and hs-CRP + ABCD2 score[ABCD2 + hs-CRP score of low risk(0-3),a score of moderate risk(4-5),a score of high risk(6-8)]were tested.In patients with cerebral infarction as the end point events occurred seventh days,the relationship between ABCD2 score and hs-CRP relation were analyzed,the difference of ABCD2,hs-CRP + ABCD2 score in evaluation of the TIA clinical prognosis were compared.Results Among 106 patients with TIA,24(22.6%)progressed to cerebral infarction.There were 33,55 and 18 patients in low-risk,moderate-risk and high-risk groups respectively.And there were 1(3.0%),12(21.8%)and 11(61.1%)progressed to cerebral infarction respectively.Along with the ABCD2 of the TIA patients was elevated,hs-CRP level presented the trend of escalation,high-risk group of patients with hs-CRP levels rose highest,followed by a moderate risk group,low risk group of hs-CRP increased the minimum.ABCD2 + hs-CRP score in the evaluation of patients with TIA was better than ABCD2 score in clinical outcome.Conclusion ABCD2 score combined with hs-CRP can improve the clinical application value of ABCD2 score,screening of high-risk TIA patients,and can be used to guide the clinical treatment.
出处
《中华脑科疾病与康复杂志（电子版）》
2012年第2期103-106,共4页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
