摘要
胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)是胆汁酸经典合成途径中的限速酶,对维持机体胆固醇代谢平衡起关键作用。目前已知CYP7A1基因的表达受包括该基因自身的多态性在内的多种因子调控。CYP7A1代谢途径作为脂类代谢通路的重要一部分,其活性发生改变后可能会引起与脂类代谢紊乱有关的胆结石、胆囊癌和心血管疾病等。就有关CYP7A1基因的最新研究进展进行了较系统的综述。
As a key rate-limiting enzyme in classical biosynthesis pathway of bile acids,cholesterol 7α-hydroxylase（CYP7A1）plays a vital role in keeping homeostasis of cholesterol metabolism.The expression of CYP7A1 is regulated by many factors including its single nucleotide polymorphisms.CYP7A1 metabolism is a part of lipids metabolic pathway,the change of its activity may lead to disease due to lipids metabolic disorder,such as gall-stone,gallbladder cancer,angiocardiopathy and so on.This paper reviewed and summarized the related research progresses on CYP7A1 gene in recent decades.
出处
《浙江农林大学学报》
CAS
CSCD
北大核心
2013年第5期755-760,共6页
Journal of Zhejiang A&F University
基金
国家现代农业产业技术体系建设专项资金资助项目(CARS-43-02)
浙江省重大科技攻关项目(2009C12079)
浙江省自然科学基金资助项目(Y3110268)
