摘要
目的探讨胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)基因多态性与阿尔茨海默病(AD)的关系。方法用PCR-RFLP方法分析7α-羟化酶A-204C多态性。结果A-204C多态性基因型频率、等位基因A、C频率在组间比较差异无显著性(P>0.05),但基因型为CC的AD患者,其TC和LDL-C水平显著高于基因型为AC的AD患者(P<0.05)。结论7α-羟化酶A-204C多态性与AD无相关性(P>0.05),但患者组CC基因型与TC、LDL-C水平密切相关(P<0.01)。
Objective To study the association of cholesterol 7α-hydroxylase （CYP7A1） gene polymorphism with Alzheimer＇ s disease（AD） .Methods cholesterol 7a-hydroxylase genotyping was performed using polymerase chain reaction-restriction fragment polymorphism. Results There was no significant difference in frequencies of allele and genotype in A-204C polymorphism between AD group and control group（ P 〉 0.05）. However, the levels of TC and LDL-C in AD patients with CC genotype was higher than that in AD patients with AC genotype（ P 〈 0.05）. Conclusion No direct association was found between the A-204C polymoiphism and AD,but there is a significant correlation between the CC genotype of the cholesterol 7α-hydroxylase gene and the levels of TC and LDL-C in AD group.
出处
《中国实验诊断学》
北大核心
2009年第7期891-892,共2页
Chinese Journal of Laboratory Diagnosis
基金
河北省科技攻关项目(06276102D-56)
